GH Sergievsky Center, Columbia University, New York, New York 10032, USA.
Epilepsia. 2013 Feb;54(2):288-95. doi: 10.1111/epi.12072. Epub 2013 Jan 7.
Although epilepsy and migraine are known to co-occur within individuals, the contribution of a shared genetic susceptibility to this comorbidity remains unclear. We investigated the hypothesis of shared genetic effects on migraine and epilepsy in the Epilepsy Phenome/Genome Project (EPGP) cohort.
We studied prevalence of a history of migraine in 730 EPGP participants aged ≥ 12 years with nonacquired focal epilepsy (NAFE) or generalized epilepsy (GE) from 501 families containing two or more individuals with epilepsy of unknown cause. Information on migraine without aura (MO) and migraine with aura (MA) was collected using an instrument validated for individuals ≥ 12 years. Because many individuals have both MO and MA, we considered two nonoverlapping groups of individuals with migraine: those who met criteria for MA in any of their headaches (MA), and those who did not ("MO-only"). EPGP participants were interviewed about the history of seizure disorders in additional nonenrolled family members. We evaluated associations of migraine prevalence in enrolled subjects with a family history of seizure disorders in additional nonenrolled relatives, using generalized estimating equations to control for the nonindependence of observations within families.
Prevalence of a history of MA (but not MO-only) was significantly increased in enrolled participants with two or more additional affected first-degree relatives.
These findings support the hypothesis of a shared genetic susceptibility to epilepsy and MA.
尽管癫痫和偏头痛在个体中经常同时发生，但这种共病是否存在共同的遗传易感性仍不清楚。我们在癫痫表型/基因组计划（EPGP）队列中研究了偏头痛与癫痫共病的遗传效应是否存在共享的假设。
我们研究了 730 名年龄≥12 岁的 EPGP 参与者中偏头痛的患病率，这些参与者患有非获得性局灶性癫痫（NAFE）或全身性癫痫（GE），来自包含两个或更多未知原因癫痫患者的 501 个家庭。使用一种针对≥12 岁人群的经过验证的工具收集无先兆偏头痛（MO）和有先兆偏头痛（MA）的信息。由于许多人同时患有 MO 和 MA，我们考虑了偏头痛的两个非重叠组：在任何头痛中符合 MA 标准的人（MA）和不符合 MA 标准的人（仅 MO）。EPGP 参与者被询问了其未入组的家庭成员中癫痫发作病史。我们使用广义估计方程来控制家庭内观察结果的非独立性，评估了偏头痛的患病率与未入组的额外一级亲属中癫痫发作病史之间的相关性。
有两个或更多一级受累亲属的入组参与者中，MA 病史（但不是仅 MO）的患病率显著增加。
这些发现支持了癫痫和 MA 存在共同遗传易感性的假设。
