Neelambike Sumana Mahadevaiah, Maheshwarappa Yogeesh D, Raghavendra Rao Morubagal, R Deepashree, Karthik Mvs Krishna, Shah Nikita K
Microbiology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IND.
Clinical Microbiology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IND.
Cureus. 2024 Nov 9;16(11):e73318. doi: 10.7759/cureus.73318. eCollection 2024 Nov.
This case report details the clinical management and implications of infection with pan-drug-resistant in a 50-year-old male admitted and diagnosed with acute peritonitis due to hollow viscus perforation, highlighting an emerging challenge in healthcare settings. Following emergency laparotomy and intensive care admission, the patient was catheterized to assist urine drainage and subsequent urine bacterial culture which yielded pan-drug-resistant , signifying a notable instance of nosocomial infection by a multi-drug-resistant organism. Despite the organism's resistance to broad-spectrum antibiotics, clinical improvement was observed with levofloxacin treatment, underlining the potential discrepancy between in vitro resistance patterns and in vivo response, particularly in urinary tract infections (UTIs) where urine drug concentrations are pivotal. This case underscores the necessity for heightened surveillance, stringent infection control measures, and judicious antibiotic use in managing infections caused by pan-drug-resistant pathogens like , challenging the traditional paradigms of antimicrobial resistance and therapy in hospital settings.
本病例报告详细介绍了一名50岁男性因中空脏器穿孔导致急性腹膜炎入院并被诊断感染泛耐药菌后的临床管理及影响,凸显了医疗机构中一个新出现的挑战。在急诊剖腹手术和入住重症监护病房后,患者接受导尿以辅助尿液引流,随后尿液细菌培养结果显示为泛耐药菌,这表明是由多重耐药菌引起的医院感染的一个显著案例。尽管该菌对广谱抗生素耐药,但左氧氟沙星治疗使患者临床症状改善,这突出了体外耐药模式与体内反应之间可能存在差异,尤其是在尿液药物浓度起关键作用的尿路感染(UTIs)中。该病例强调了在管理由泛耐药病原体如[具体菌名未给出]引起的感染时,加强监测、严格的感染控制措施和合理使用抗生素的必要性,对医院环境中抗菌药物耐药性和治疗的传统模式提出了挑战。