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下唇口腔疣状黄瘤：一种罕见的病变。

Oral Verruciform Xanthoma of the Lower Lip: A Rare Entity.

作者信息

Chatterjee Ananjan, Purkait Swapan K, Banerjee Ishita, Banerjee Abhishek, Ramalingam Karthikeyan

机构信息

Oral and Maxillofacial Pathology, Buddha Institute of Dental Sciences and Hospital, Patna, IND.

Pediatric and Preventive Dentistry, Guru Nanak Institute of Dental Sciences & Research, Kolkata, IND.

出版信息

Cureus. 2024 Nov 9;16(11):e73352. doi: 10.7759/cureus.73352. eCollection 2024 Nov.

DOI:10.7759/cureus.73352
PMID:39659335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11628199/
Abstract

Oral verruciform xanthoma (OVX) is a rare entity, and only a handful of cases have been reported in the literature to date. This innocent-looking lesion can mimic any benign epithelial or connective tissue origin neoplasm. It can present with variations in surface color and texture. Cases have been reported in intra-osseous and extra-osseous sites, mainly in masticatory mucosa and very few in non-keratinized mucosal sites. Literature suggests the xanthoma cells possess a monocyte/macrophage lineage, although the exact etiopathogenesis remains unclear. Our patient was a 20-year-old male who presented with a soft, keratotic growth in the lower lip. It clinically mimicked a mucocele or a traumatic fibroma until the mystery was resolved by histopathology and immunohistochemistry. Histopathology revealed numerous foamy, granular xanthoma cells in the stroma along with inflammation and hyperplastic epithelium. Immunohistochemistry showed positivity to CD68 and Cathepsin-B but negative to S-100. The final diagnosis was made as oral verruciform xanthoma. It was surgically excised and remained recurrence-free on follow-up.

摘要

口腔疣状黄瘤（OVX）是一种罕见的病变，迄今为止文献中仅报道了少数病例。这种看似无害的病变可模仿任何起源于良性上皮或结缔组织的肿瘤。它可表现为表面颜色和质地的变化。已有病例报道发生于骨内和骨外部位，主要位于咀嚼黏膜，非角化黏膜部位则非常少见。文献表明，黄瘤细胞具有单核细胞/巨噬细胞谱系，但其确切的病因发病机制仍不清楚。我们的患者是一名20岁男性，下唇出现一个柔软的角化性肿物。临床上它酷似黏液囊肿或创伤性纤维瘤，直到通过组织病理学和免疫组织化学才揭开谜底。组织病理学显示，间质中有大量泡沫状、颗粒状黄瘤细胞，伴有炎症和上皮增生。免疫组织化学显示CD68和组织蛋白酶B呈阳性，而S-100呈阴性。最终诊断为口腔疣状黄瘤。通过手术将其切除，随访期间未复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/af28f2a50295/cureus-0016-00000073352-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/4c1ea13d8a4e/cureus-0016-00000073352-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/564c8c6a5fd7/cureus-0016-00000073352-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/583da8c7fd20/cureus-0016-00000073352-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/c88debadb229/cureus-0016-00000073352-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/12ef1537fcf6/cureus-0016-00000073352-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/4cb0ac6ddda2/cureus-0016-00000073352-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/4361cb545e26/cureus-0016-00000073352-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/af28f2a50295/cureus-0016-00000073352-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/4c1ea13d8a4e/cureus-0016-00000073352-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/564c8c6a5fd7/cureus-0016-00000073352-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/583da8c7fd20/cureus-0016-00000073352-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/c88debadb229/cureus-0016-00000073352-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/12ef1537fcf6/cureus-0016-00000073352-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/4cb0ac6ddda2/cureus-0016-00000073352-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/4361cb545e26/cureus-0016-00000073352-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c565/11628199/af28f2a50295/cureus-0016-00000073352-i08.jpg

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本文引用的文献

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The Diagnostic Considerations and Clinical Management of Lower Lip Swellings in Adolescents: A Narrative Review.青少年下唇肿胀的诊断考量与临床处理：一项叙述性综述
Cureus. 2024 Oct 17;16(10):e71707. doi: 10.7759/cureus.71707. eCollection 2024 Oct.
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Oral verruciform xanthomas mimicking potentially malignant disorders.酷似潜在恶性疾病的口腔疣状黄瘤。
J Clin Exp Dent. 2024 Apr 1;16(4):e539-e542. doi: 10.4317/jced.61411. eCollection 2024 Apr.
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Oral verrucous xanthoma with oral lichen planus: a case report.口腔疣状黄瘤合并口腔扁平苔藓：一例报告。
Hua Xi Kou Qiang Yi Xue Za Zhi. 2023 Feb 1;41(1):104-109. doi: 10.7518/hxkq.2023.01.014.
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Verruciform Xanthoma: Clinical and Morphologic Spectrum Across Oral, Genital, and Cutaneous Sites.疣状黄瘤：口腔、生殖器和皮肤部位的临床和形态学谱。
Head Neck Pathol. 2023 Sep;17(3):673-678. doi: 10.1007/s12105-023-01568-4. Epub 2023 Jul 7.
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Verruciform Xanthoma of the Ventral Surface of the Tongue: A Rare Case Report and Literature Review.舌腹面疣状黄色瘤：1例罕见病例报告及文献复习
Iran J Otorhinolaryngol. 2021 Jan;33(114):55-59. doi: 10.22038/ijorl.2020.45912.2506.
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CD163 Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study.CD163 泡沫状巨噬细胞通过血管内皮生长因子（VEGF）表达介导的血管生成与口腔疣状黄瘤的形态发生相关：一项免疫组织化学研究
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