Jin Annie, Haynes Dylan, Rodriguez Olaf, Park Ji Hye, Jellinek Nathaniel, Rubin Adam I
Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Skin Appendage Disord. 2024 Dec;10(6):443-458. doi: 10.1159/000539383. Epub 2024 Jul 15.
A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor.
This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma. Optimal surgical sampling techniques for each lesion are presented.
In summary, the clinical and histopathologic features of several common and rare nail unit tumors and the optimal sampling techniques for each lesion are presented in this manuscript. Knowledge of the clinical and histopathologic features of these tumors informs the surgical approach to them and will produce the best patient outcomes.
多种肿瘤可累及甲单位，其中一些常被误诊为炎症性或感染性疾病。获取用于组织病理学评估的最佳样本需要了解甲单位的解剖结构以及疑似甲肿瘤的组织病理学。
本综述讨论了一部分良性和恶性甲肿瘤的临床和组织病理学特征，包括甲下黑色素瘤、甲单位原位鳞状细胞癌、甲单位鳞状细胞癌、甲母质瘤、甲乳头状瘤、甲母质嗜甲细胞肿瘤和嗜甲细胞癌。介绍了针对每种病变的最佳手术取样技术。
总之，本文阐述了几种常见和罕见甲单位肿瘤的临床和组织病理学特征以及每种病变的最佳取样技术。了解这些肿瘤的临床和组织病理学特征有助于制定针对它们的手术方案，并将产生最佳的患者治疗效果。
