纵向红甲症提示的甲棘层松解性角化不良性棘皮瘤
Acantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.
作者信息
Chamli Amal, Fazzeni Maryem, Helal Imen, Frioui Refka, Hammami Houda, Zaouak Anissa, Fenniche Samy
机构信息
Dermatology Department, Habib Thameur Hospital, "Genodermatoses and Cancers LR12SP03", Tunis, Tunisia.
University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.
出版信息
Skin Appendage Disord. 2024 Dec;10(6):532-535. doi: 10.1159/000539465. Epub 2024 Jun 26.
INTRODUCTION
Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.
CASE PRESENTATION
A 63-year-old female patient consulted for a longitudinal erythronychia (LE) associated with distal onycholysis. Dermoscopy showed LE with a few splinter hemorrhages, with localized hyperkeratosis and thinning of the nail plate at the free edge. Histopathology confirmed the diagnosis of ADA.
CONCLUSION
ADA is a rare tumor that could mimic various inflammatory or neoplastic conditions. To our knowledge, this is the eighth reported case in the literature. This uncommon entity could mimic various inflammatory or neoplastic conditions.
引言
局灶性棘层松解性角化不良是一种独特的组织学模式，于1972年由阿克曼首次描述，表现为表皮内局灶性基底层上裂隙以及表皮各层的角化不良细胞，伴有角化过度和不全角化。1990年报道了首例甲下棘层松解性角化不良棘皮瘤（ADA）。这种甲下变异型是一种非常罕见的疾病。
病例报告
一名63岁女性患者因伴有远端甲剥离的纵向红甲就诊。皮肤镜检查显示纵向红甲伴有少量裂片样出血，游离缘有局限性角化过度和甲板变薄。组织病理学确诊为ADA。
结论
ADA是一种罕见肿瘤，可模仿多种炎症性或肿瘤性疾病。据我们所知，这是文献中报道的第八例病例。这种罕见疾病可模仿多种炎症性或肿瘤性疾病。
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