Huang Caizhi, Zhang Cong, Zhang Jie
Department of Laboratory Medicine, Hunan Children's Hospital, Changsha, Hunan Province, 410007, People's Republic of China.
J Inflamm Res. 2024 Dec 6;17:10547-10556. doi: 10.2147/JIR.S489233. eCollection 2024.
This study aimed to evaluate the association between vitamin D and molecules related to vitamin D metabolism in children with sepsis.
A total of 98 hospitalized children with sepsis were included in this study. Blood samples were collected within the first 4 h of admission. Blood vitamin D; molecules related to vitamin D metabolism including vitamin-D-binding protein (VDBP), 7-dehydrocholesterol reductase (DHCR7), 25-hydroxylase (CYP2R1), 24-hydroxylase (CYP24A1), and cathelicidin (CATH); and other inflammatory markers including interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP), and white blood cell count (WBC) were measured.
Of the enrolled children, 23.47% (23/98) were confirmed to have severe sepsis, and 10.20% (10/98) died. The prevalence of hypovitaminosis D was 46.94% (46/98) in the children with sepsis. Children with hypovitaminosis D had lower levels of CYP2R1 and CATH and higher levels of CYP24A1, PCT, and IL-6 compared to children with vitamin D sufficiency. Blood vitamin D level was positively correlated with blood VDBP, CYP2R1, and CATH and negatively correlated with CYP24A1, PCT, and IL-6. Blood vitamin D was not independently associated with severe sepsis and mortality, but it was independently associated with the requirement of intensive care unit (ICU) stay.
Molecules related to vitamin D metabolism such as VDBP, CYP2R1, and CYP24A1 are involved in regulating the levels of circulating vitamin D. Children with sepsis had a high prevalence of hypovitaminosis D. Hypovitaminosis D was independently associated with the requirement of ICU stay in children with sepsis.
本研究旨在评估脓毒症患儿维生素D与维生素D代谢相关分子之间的关联。
本研究共纳入98例住院脓毒症患儿。在入院后的前4小时内采集血样。检测血维生素D；与维生素D代谢相关的分子，包括维生素D结合蛋白（VDBP）、7-脱氢胆固醇还原酶（DHCR7）、25-羟化酶（CYP2R1）、24-羟化酶（CYP24A1）和杀菌肽（CATH）；以及其他炎症标志物，包括白细胞介素-6（IL-6）、降钙素原（PCT）、C反应蛋白（CRP）和白细胞计数（WBC）。
在纳入的患儿中，23.47%（23/98）被确诊为严重脓毒症，10.20%（10/98）死亡。脓毒症患儿维生素D缺乏症的患病率为46.94%（46/98）。与维生素D充足的患儿相比，维生素D缺乏症患儿的CYP2R1和CATH水平较低，而CYP24A1、PCT和IL-6水平较高。血维生素D水平与血VDBP、CYP2R1和CATH呈正相关，与CYP24A1、PCT和IL-6呈负相关。血维生素D与严重脓毒症和死亡率无独立关联，但与入住重症监护病房（ICU）的需求独立相关。
VDBP、CYP2R1和CYP24A1等与维生素D代谢相关的分子参与调节循环维生素D水平。脓毒症患儿维生素D缺乏症的患病率较高。维生素D缺乏症与脓毒症患儿入住ICU的需求独立相关。
