Lu Yue, Cai Tiantian, Gao Juanjuan, Ren Yangge, Ding Yi, Liu Shujing, Liu Linyuan, Huang Hao, Wang Haijie, Wang Chengji, Wang Wei, Shen Ruling, Zhu Bo, Jia Lin
Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Shanghai Laboratory Animal Research Center, Jinke Street 3577, Shanghai, 201203, China.
Mater Today Bio. 2024 Nov 21;29:101355. doi: 10.1016/j.mtbio.2024.101355. eCollection 2024 Dec.
The goal of combination cancer therapy, including chemo-phototherapy, is to achieve highly efficient antitumor effects while minimizing the adverse reactions associated with conventional chemotherapy. Nevertheless, enhancing the contribution of non-chemotherapeutic strategies in combination therapy is often challenging because this requires multiple active ingredients to be encapsulated in a single delivery system. However, most commonly used photothermal reagents are challenging to be loaded in large quantities and have poor biocompatibility. Herein, we developed photothermal co-micelles through a co-assembly strategy using a cholesterol-based liquid crystal block copolymer (LC-BCP) with disulfide bonds in the side chain of the LC blocks and a croconaine-based amphiphile (CBA) containing a cholesterol moiety. This approach allowed the CBA to be effectively embedded within LC-BCPs, serving as the functional component of the drug-loaded carrier. These co-micelles could encapsulate doxorubicin (DOX), showed tunable reduction-responsive drug release, and enabled near-infrared laser-triggered photothermal therapy as well as fluorescence and photothermal imaging. Following laser irradiation, the photothermal activity of the co-micelles rapidly induced tumor cell death and accelerated drug release. and experiments demonstrated that the synergistic photo-chemotherapeutic effects of these drug-loaded co-micelles offer a promising avenue for synergistic precision photothermal-chemotherapy.
包括化学光热疗法在内的联合癌症治疗的目标是在实现高效抗肿瘤效果的同时，将与传统化疗相关的不良反应降至最低。然而，增强联合治疗中非化疗策略的作用往往具有挑战性，因为这需要将多种活性成分封装在单个递送系统中。然而，大多数常用的光热试剂难以大量负载且生物相容性较差。在此，我们通过共组装策略开发了光热共胶束，使用基于胆固醇的液晶嵌段共聚物（LC-BCP），其在LC嵌段的侧链中含有二硫键，以及一种基于番红花碱的两亲物（CBA），其含有胆固醇部分。这种方法使CBA能够有效地嵌入LC-BCP中，作为载药载体的功能成分。这些共胶束可以封装阿霉素（DOX），显示出可调节的还原响应性药物释放，并能够实现近红外激光触发的光热疗法以及荧光和光热成像。激光照射后，共胶束的光热活性迅速诱导肿瘤细胞死亡并加速药物释放。实验表明，这些载药共胶束的协同光化学治疗效果为协同精准光热化疗提供了一条有前景的途径。
