State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China.
Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita 564-8680, Japan.
ACS Appl Bio Mater. 2023 Nov 20;6(11):4504-4517. doi: 10.1021/acsabm.3c00518. Epub 2023 Oct 12.
Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has been extensively studied in recent years because of its noninvasive properties, high efficiency, improved selectivity, and reduced side effects. Gold nanoclusters (AuNCs) have the advantages of high biocompatibility, high biosafety, excellent photoresponse, and high tumor penetration ability. This review analyzes the use of AuNCs in tumor phototherapy in recent years from three aspects, namely, AuNCs in PDT, AuNCs in PTT, and AuNCs in combination therapy, and presents the high potential of AuNCs in cancer phototherapy. This review aims to provide readers with the unique advantages, diversified application approaches, and bright application prospects of AuNCs in phototherapy and to provide insights into strategies for applying AuNCs to tumor phototherapy.
癌症光疗，包括光动力疗法（PDT）和光热疗法（PTT），由于其具有非侵入性、高效、选择性提高和副作用降低等特点，近年来得到了广泛的研究。金纳米簇（AuNCs）具有高生物相容性、高生物安全性、优异的光响应性和高肿瘤穿透能力等优点。本文从 AuNCs 在 PDT、AuNCs 在 PTT 和 AuNCs 联合治疗三个方面分析了近年来 AuNCs 在肿瘤光疗中的应用，并展示了 AuNCs 在癌症光疗中的高潜力。本文旨在为读者提供 AuNCs 在光疗中独特的优势、多样化的应用方法和光明的应用前景，并为 AuNCs 在肿瘤光疗中的应用策略提供思路。
