Lai Yu, Jiang Jialing, Zhang Huize, Gong Kang
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Drug Des Devel Ther. 2024 Dec 6;18:5743-5758. doi: 10.2147/DDDT.S494758. eCollection 2024.
Curcumin, the main active compound in turmeric, has garnered significant interest for its wide range of pharmacological properties. In this study, CiteSpace was used to visually analyze curcumin-related publications to elucidate the current landscape and explore emerging frontiers in curcumin research. In total, 23,184 publications on curcumin from January 1, 2014, to December 31, 2023, were scrutinized. The analysis revealed that publication volume consistently increased over time. The top 10 countries contributed 90.87% of the publications, highlighting the global significance of curcumin research. China generated 31.34% of the total corpus due to its strong research capabilities and traditional medicine culture. The top 10 institutions contributed 11.21% of the articles, revealing notable collaborations. Among the prolific authors, Amirhossein Sahebkar produced 246 publications, whereas Preetha Anand garnered the most citations. Keyword analysis revealed prevalent trends such as "fabrication", "combination", "extract", "natural products", "colorectal cancer", and "resveratrol". Reference analysis emphasized research on therapeutic and modulatory effects, anticancer potential, and interdisciplinary topics, such as molecular biology, chemistry, and nutrition. More importantly, we simplified cluster relationships by selecting the top 30% of cluster dependency paths. For instance, the references within the #1 polymeric micelle cite literature from the #2 anticancer potential, #3 modulatory effect, and #4 therapeutic effect, indicating that clusters 2, 3, and 4 serve as knowledge foundations for cluster 1. This interconnectedness highlights how the information in these clusters can contribute to the knowledge of curcumin in various studies. This study provides an overview of the research trends and critical themes related to curcumin, offering insights for future research directions and emphasizing the interdisciplinary and global scope of curcumin research.
姜黄素是姜黄中的主要活性化合物，因其广泛的药理特性而备受关注。在本研究中，使用CiteSpace对姜黄素相关出版物进行可视化分析，以阐明当前的研究态势，并探索姜黄素研究的新兴前沿领域。总共审查了2014年1月1日至2023年12月31日期间关于姜黄素的23184篇出版物。分析表明，出版物数量随时间持续增加。排名前十的国家贡献了90.87%的出版物，凸显了姜黄素研究的全球重要性。由于强大的研究能力和传统医学文化，中国产出了占总量31.34%的文献。排名前十的机构贡献了11.21%的文章，显示出显著的合作。在多产作者中，阿米尔侯赛因·萨赫布卡尔发表了246篇出版物，而普里莎·阿南德获得的引用最多。关键词分析揭示了“制备”“组合”“提取物”“天然产物”“结直肠癌”和“白藜芦醇”等普遍趋势。参考文献分析强调了对治疗和调节作用、抗癌潜力以及分子生物学、化学和营养等跨学科主题的研究。更重要的是，我们通过选择30%的聚类依赖路径来简化聚类关系。例如，#1聚合物胶束内的参考文献引用了#2抗癌潜力、#3调节作用和#4治疗作用的文献，表明聚类2、3和4是聚类1的知识基础。这种相互关联性凸显了这些聚类中的信息如何能在各种研究中为姜黄素知识做出贡献。本研究概述了与姜黄素相关的研究趋势和关键主题，为未来研究方向提供了见解，并强调了姜黄素研究的跨学科性和全球范围。
