Hong Qing, Lyu Wei, Zhang Chaowei, Yao Weiyi, Han Yuxuan, Chen Na
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
School of Economics and Management, Anhui Polytechnic University, Wuhu, China.
Front Immunol. 2025 Mar 24;16:1559670. doi: 10.3389/fimmu.2025.1559670. eCollection 2025.
Curcumin has a clear immunopharmacological effect and plays an important role as an immune agent in various immune diseases and tumor immunotherapy. To comprehensively and scientifically clarify and reflect the development process, current status, and research trends of curcumin in the field of immune regulation, and to provide reliable insights for discipline development strategies and future research expansion, this study systematically analyzes 3939 valid articles related to curcumin and immunity published between 2004 and 2024 from the Web of Science database. Using Citespace and R-bibliometrix software for bibliometric analysis, we create visual knowledge maps from multiple dimensions including overall publication output, influential research entities, highly cited papers, research topics and hotspots. The results indicate that the overall number of publications and citations is currently in a rapid development phase. China occupies a core position in this research field but has low collaboration intensity. The Egyptian Knowledge Bank (EKB) is the institution with the highest publication volume. Moreover, cluster analysis reveals that research hotspots are gradually shifting from fundamental pathology to topics involving broad social and environmental influences. The top five keywords with the most explosive citations-curcumin, inflammation, apoptosis, oxidative stress, and cancer-represent the most focused and influential research topics. Currently, curcumin immunology has developed a diversified research perspective, accumulating significant research in the areas of active substance basis, pharmacological activity, anti-inflammatory, and anti-cancer studies. The thematic evolution trends and keywords related to curcumin's immunological mechanisms summarized in this article provide insights and guidance for future research directions.
姜黄素具有明确的免疫药理作用，在各种免疫疾病和肿瘤免疫治疗中作为免疫剂发挥着重要作用。为全面、科学地阐明和反映姜黄素在免疫调节领域的发展历程、现状及研究趋势，为学科发展战略和未来研究拓展提供可靠参考，本研究系统分析了2004年至2024年间从Web of Science数据库中检索到的3939篇与姜黄素和免疫相关的有效文章。利用Citespace和R-bibliometrix软件进行文献计量分析，从总体发表量、有影响力的研究实体、高被引论文、研究主题和热点等多个维度创建可视化知识图谱。结果表明，目前的出版物和被引次数总体处于快速发展阶段。中国在该研究领域占据核心地位，但合作强度较低。埃及知识库（EKB）是发表量最高的机构。此外，聚类分析显示研究热点正逐渐从基础病理学转向涉及广泛社会和环境影响的主题。引用爆发力最强的前五个关键词——姜黄素、炎症、细胞凋亡、氧化应激和癌症——代表了最受关注和最具影响力的研究主题。目前，姜黄素免疫学已形成多元化的研究视角，在活性物质基础、药理活性、抗炎和抗癌研究等方面积累了大量研究成果。本文总结的姜黄素免疫机制的主题演变趋势和关键词为未来研究方向提供了见解和指导。
