Chervinskaya Irina, Kuprina Nadezhda I, Kruglikov Ilja
Clinic DK Forma, St. Petersburg, Russian Federation.
North-West Public Health Research Center, St. Petersburg, Russian Federation.
Clin Cosmet Investig Dermatol. 2024 Dec 6;17:2779-2794. doi: 10.2147/CCID.S488977. eCollection 2024.
In this single-centre, retrospective, pragmatic, longitudinal case-series clinical study triple-frequency LDM (TF-LDM) technology with frequencies of 1/3/10 MHz and 3/10/19 MHz was applied for treatment of cellulite to reveal the effect of these waves on the cellulite skin and assess the sustainability of treatment outcomes during the long-term follow-up controls.
Twenty Caucasian females with mild-to-severe gynoid lipodystrophy aged 27-53 years who received cellulite monotherapy with TF-LDM were included in this study. All participants were evaluated at three time points: baseline (T1), on the day of the last treatment (T2), and during the last follow-up (T3). Cellulite severity was assessed by six independent clinicians using the five-grade Clinician-Reported Photonumeric Cellulite Severity Scale (CR-PCSS). Patient satisfaction was evaluated using a 10-grade GAIS scale, ranging from 0 to 10 (0 - dissatisfied; 10 - fully satisfied). To objectify the treatment outcomes, 17 subjects were investigated using B-mode ultrasonography and real-time compression elastography at baseline and during follow-up.
The average values of CR-PCSS (T1), CR-PCSS (T2) and CR-PCSS (T3) over all participants were 2.22±0.82, 1.18±0.77, and 0.84±0.77, respectively, which corresponded to the skin improvement between T1 and T2 of 0.93±0.27 (p < 0.0001) as well as between T1 and T3 of 1.38±0.47 (p < 0.0001). Assessment of elasticity of the dermis and adipose tissue on the basis of the 5-grade coloration scale revealed significant reinforcement of both tissues as well as of the superficial fascia at follow-up as compared to their baseline values. The obtained treatment outcomes were long-lasting and could be clearly observed even in individuals with a long-term follow-ups. Assessment of the satisfaction of participants with the treatment results revealed a high satisfaction of 8.95 ± 1.49. The method demonstrated no side effects, was pain-free, well-tolerated, and highly accepted by patients.
在这项单中心、回顾性、实用性、纵向病例系列临床研究中，应用频率为1/3/10兆赫和3/10/19兆赫的三频低能量激光疗法（TF-LDM）治疗橘皮组织，以揭示这些波段对橘皮组织皮肤的影响，并在长期随访对照中评估治疗效果的可持续性。
本研究纳入了20名年龄在27至53岁之间、患有轻至重度女性型脂肪营养不良的白人女性，她们接受了TF-LDM橘皮组织单一疗法。所有参与者在三个时间点接受评估：基线（T1）、最后一次治疗当天（T2）和最后一次随访期间（T3）。由六名独立的临床医生使用五级临床医生报告的光子数字橘皮组织严重程度量表（CR-PCSS）评估橘皮组织严重程度。使用0至10分的GAIS量表评估患者满意度（0 - 不满意；10 - 完全满意）。为了客观化治疗效果，在基线和随访期间对17名受试者进行了B型超声检查和实时压缩弹性成像。
所有参与者的CR-PCSS（T1）、CR-PCSS（T2）和CR-PCSS（T3）的平均值分别为2.22±0.82、1.18±0.77和0.84±0.77，这对应于T1和T2之间皮肤改善为0.93±0.27（p < 0.0001）以及T1和T3之间为1.38±0.47（p < 0.0001）。根据五级着色量表对真皮和脂肪组织的弹性评估显示，与基线值相比，随访时这两种组织以及浅筋膜均有明显增强。所获得的治疗效果是持久的，即使在长期随访的个体中也能清楚观察到。对参与者对治疗结果的满意度评估显示满意度较高，为8.95±1.49。该方法未显示出副作用，无痛，耐受性良好，且患者高度接受。
