Ye Hui, Chen Weifeng, Liu Wenyan, Zhu Junhui, Liang Jingyao, Zhang Xibao
Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong, 510095, People's Republic of China.
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, 510095, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Dec 5;17:2767-2771. doi: 10.2147/CCID.S485694. eCollection 2024.
Darier's disease (DD) is a rare chronic keratinizing skin disease characterized by dyskeratosis of epidermal cells. We report a case of DD with a medical history spanning over 20 years and recurring symptoms. Pathologically confirmed DD was treated with a combination of abrocitinib and acitretin, resulting in rapid symptom resolution within 2 weeks. No recurrence was noted in an 11-week follow-up. The mechanism may involve acitretin's inhibition of proliferation and anti-inflammation, while abrocitinib acts on IL-6 implicated in DD pathogenesis, exerting an immunomodulatory and anti-inflammatory effect, leading to rapid symptom relief. The combination of abrocitinib and acitretin is an effective therapy for DD, offering a promising new option for refractory patients.
Darier病（DD）是一种罕见的慢性角化性皮肤病，其特征为表皮细胞的角化异常。我们报告一例病史超过20年且症状反复的DD病例。经病理证实的DD患者接受了阿布昔替尼和阿维A联合治疗，2周内症状迅速缓解。在11周的随访中未观察到复发。其机制可能涉及阿维A对增殖的抑制和抗炎作用，而阿布昔替尼作用于与DD发病机制相关的IL-6，发挥免疫调节和抗炎作用，从而迅速缓解症状。阿布昔替尼和阿维A联合治疗是DD的有效疗法，为难治性患者提供了一个有前景的新选择。
