Duarte Junior Miguel Angelo, Pintos-Carrillo Salud, Hernández-Martínez Alba, López-Gil José Francisco, Graciani Auxiliadora, Banegas José Ramón, Rodríguez-Artalejo Fernando, Cabanas-Sánchez Verónica, Martinez-Gomez David
Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid; CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.
Department of Education, Faculty of Education Sciences, Universidad de Almería, Almería, Spain.
J Gerontol A Biol Sci Med Sci. 2025 Feb 10;80(3). doi: 10.1093/gerona/glae291.
We assessed the association of adherence to the guidelines and subsequent changes over time in adherence with all-cause mortality.
We used data from 3 518 and 3 273 older adults, aged 60-96 years at baseline, from Seniors-ENRICA 1 and 2 cohorts, respectively. Adherence to 24-hour movement guidelines was defined as ≥150 min/wk of moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB) ≤8 h/d (including ≤3 h/d of recreational screen time), and 7-9 h/d of sleep if aged 18-64 years or 7-8 h/d if aged ≥65 years. All-cause mortality was ascertained up to January 31, 2024. Analyses were performed using Cox regression adjusted for the main confounders.
Of the 6 613 participants with complete data, 1 353 died during a mean follow-up of 10.1 (standard deviation [SD] = 4.0) years. Meeting MVPA (hazard ratio [HR] 0.73; 95% confidence interval [CI] 0.65-0.82), SB (HR 0.89; 95% CI 0.80-0.99), and sleep (HR 0.89; 95% CI 0.80-0.99) recommendations were associated with lower mortality. Also, we noticed a reduction in mortality in meeting MVPA combined with both SB (34%) and sleep (12%), sleep and SB combined (23%), and meeting all 24-hour movement guidelines (40%). Changes in meeting 24-hour movement guidelines occurred between a mean follow-up of 2.8 (0.6) years. Meeting 24-hour movement guidelines at baseline and follow-up is associated with lower mortality (HR 0.69; 95% CI 0.47-0.99), compared to not meet them at both examinations.
This prospective cohort study underscores the critical impact of adhering to and maintaining adherence to the 24-hour movement guidelines in reducing mortality risk among older adults.
我们评估了遵循指南情况与随后遵循情况随时间变化对全因死亡率的影响。
我们分别使用了来自Seniors-ENRICA 1和2队列中3518名和3273名基线年龄为60 - 96岁的老年人的数据。遵循24小时运动指南的定义为：每周进行≥150分钟的中等至剧烈身体活动（MVPA），久坐行为（SB）≤8小时/天（包括娱乐屏幕时间≤3小时/天），18 - 64岁者睡眠时间为7 - 9小时/天，≥65岁者睡眠时间为7 - 8小时/天。截至2024年1月31日确定全因死亡率。分析采用对主要混杂因素进行调整的Cox回归。
在6613名有完整数据的参与者中，1353人在平均10.1年（标准差[SD]=4.0）的随访期间死亡。达到MVPA（风险比[HR]0.73；95%置信区间[CI]0.65 - 0.82）、SB（HR 0.89；95% CI 0.80 - 0.99）和睡眠（HR 0.89；95% CI 0.80 - 0.99）建议与较低死亡率相关。此外，我们注意到达到MVPA并同时达到SB（降低34%）和睡眠（降低12%）、睡眠和SB同时达到（降低23%）以及达到所有24小时运动指南（降低40%）的人群死亡率降低。达到24小时运动指南的变化发生在平均2.8（0.6）年的随访期间。与两次检查均未达到相比，在基线和随访时达到24小时运动指南与较低死亡率相关（HR 0.69；95% CI 0.47 - 0.99）。
这项前瞻性队列研究强调了遵循并持续遵循24小时运动指南对降低老年人死亡风险的关键影响。
