Duarte Junior Miguel Angelo, Martinez-Gomez David, Pintos-Carrillo Salud, Lopez-Garcia Esther, Rodríguez-Artalejo Fernando, Cabanas-Sánchez Verónica
Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Calle Arzobispo Morcillo 4, 28029, Madrid, Spain.
CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Geroscience. 2025 Apr;47(2):1699-1711. doi: 10.1007/s11357-024-01351-5. Epub 2024 Sep 20.
We examined associations between nighttime sleep and midday nap duration with all-cause mortality according to adherence to moderate-to-vigorous physical activity (MVPA) recommendations in older adults. We used data from 3518 and 3273 older adults recruited in the Seniors-ENRICA-1 and 2 cohorts, respectively. Nighttime sleep time was classified as short (< 7 h), middle (≥ 7 and < 8 h), and long (≥ 8 h), and midday napping as no nap, short (≤ 30 min), long (> 30 and ≤ 60 min), and very long (> 60 min). Time spent in MVPA was classified as meeting (i.e., ≥ 150 min/week) or not the MVPA recommendations. All-cause mortality was the main outcome. Analyses were performed with Cox regression and adjusted for the main confounders. Overall, compared with middle nighttime sleep, both short (HR 1.20; 95% CI 1.03-1.39) and long (HR 1.30; 95% CI 1.12-1.52) were associated with higher mortality. Among participants who did not meet MVPA recommendations, the association between short (HR 1.22; 95% CI 1.01-1.48) and long (HR 1.46; 95% CI 1.21-1.77) sleeping duration mortality remained. Short napping was associated with lower mortality (HR 0.83; 95% CI 0.71-0.96) and very long with higher mortality (HR 1.29; 95% CI 1.04-1.59), compared to those who did not nap. Among participants not meeting MVPA recommendations, only very long napping was associated with increased mortality (HR 1.32; 95% CI 1.01-1.73). No associations were identified between nighttime sleep or midday napping with mortality among participants meeting MVPA recommendations. Meeting MVPA recommendations can attenuate the risks associated with short or long sleep duration.
我们根据老年人对中度至剧烈身体活动（MVPA）建议的依从性，研究了夜间睡眠时间和午睡时长与全因死亡率之间的关联。我们分别使用了从老年人-ENRICA-1和2队列中招募的3518名和3273名老年人的数据。夜间睡眠时间分为短（<7小时）、中（≥7且<8小时）和长（≥8小时），午睡情况分为无午睡、短（≤30分钟）、长（>30且≤60分钟）和非常长（>60分钟）。MVPA的时长分为符合（即≥150分钟/周）或不符合MVPA建议。全因死亡率是主要结局。采用Cox回归进行分析，并对主要混杂因素进行了校正。总体而言，与夜间睡眠时长中等的情况相比，短睡眠（风险比[HR] 1.20；95%置信区间[CI] 1.03 - 1.39）和长睡眠（HR 1.30；95% CI 1.12 - 1.52）均与较高的死亡率相关。在未达到MVPA建议的参与者中，短睡眠（HR 1.22；95% CI 1.01 - 1.48）和长睡眠时长（HR 1.46；95% CI 1.21 - 1.77）与死亡率之间的关联依然存在。与不午睡的人相比，短午睡与较低的死亡率相关（HR 0.83；95% CI 0.71 - 0.96），而非常长的午睡与较高的死亡率相关（HR 1.29；95% CI 1.04 - 1.59）。在未达到MVPA建议的参与者中，只有非常长的午睡与死亡率增加相关（HR 1.32；95% CI 1.01 - 1.73）。在达到MVPA建议的参与者中，未发现夜间睡眠或午睡与死亡率之间存在关联。达到MVPA建议可以减轻与短睡眠或长睡眠时长相关的风险。
