Su Guangming, Huang Ping, Liu Dan, Xing Guorui, Guo Ruochun, Li Shenghui, Fan Shao, Cheng Lin, Yan Qiulong, Yang Wei
Department of Laboratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Gastroenterology, Harbin First Hospital, Harbin, China.
Microbiol Spectr. 2025 Jan 7;13(1):e0218224. doi: 10.1128/spectrum.02182-24. Epub 2024 Dec 11.
The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like , , and , with and showing the most significant changes (Wilcoxon rank-sum test, < 0.001, fold change >10). Network analysis revealed a less interconnected and more uneven gut microbial network in ACVD patients. Network key taxa identified in the ACVD gut microbiome network include c182, c88, c192, and c22. Predictive models that integrated both bacterial and fungal taxa enhanced prediction accuracy, underscoring the critical role of gut fungi in ACVD. Our findings offer a thorough understanding of the link between the gut mycobiome and ACVD progression, which is vital for directing future therapeutic research.IMPORTANCEACVD is a leading cause of death and morbidity worldwide. While the role of the gut microbiome in ACVD development is recognized, the contribution of the gut mycobiome remains largely unexplored. Our study reveals significant alterations in the gut mycobiome of ACVD patients and identifies key fungal taxa associated with the disease. These findings underscore the importance of the gut mycobiome in the pathogenesis of ACVD and offer new avenues for developing preventive and therapeutic strategies targeting the gut fungal community. Our results provide valuable insights into the complex interplay between gut fungi and bacteria in ACVD, paving the way for novel therapeutic approaches.
肠道真菌群落与动脉粥样硬化性心血管疾病（ACVD）之间的联系在很大程度上尚不清楚。在我们的研究中，我们使用鸟枪法宏基因组测序比较了214例ACVD患者与171例健康对照者的肠道真菌群落，并研究了它们与肠道细菌群落和网络关键分类群的相互作用。ACVD患者的肠道真菌群落组成存在显著差异，显示出如、和等机会性病原体增加，其中和的变化最为显著（Wilcoxon秩和检验，<0.001，变化倍数>10）。网络分析显示，ACVD患者的肠道微生物网络连接性较低且更加不均衡。在ACVD肠道微生物网络中识别出的网络关键分类群包括c182、c88、c192和c22。整合细菌和真菌分类群的预测模型提高了预测准确性，突出了肠道真菌在ACVD中的关键作用。我们的研究结果全面了解了肠道真菌群落与ACVD进展之间的联系，这对于指导未来的治疗研究至关重要。重要性ACVD是全球死亡和发病的主要原因。虽然肠道微生物群在ACVD发展中的作用已得到认可，但肠道真菌群落的贡献在很大程度上仍未得到探索。我们的研究揭示了ACVD患者肠道真菌群落的显著变化，并确定了与该疾病相关的关键真菌分类群。这些发现强调了肠道真菌群落在ACVD发病机制中的重要性，并为开发针对肠道真菌群落的预防和治疗策略提供了新途径。我们的结果为ACVD中肠道真菌与细菌之间的复杂相互作用提供了有价值的见解，为新的治疗方法铺平了道路。
