Dong Yingbo, Chen Congxin, Li Yuting, Cao Peiyu, Tang Yilin, Xu Guoxin, Si Qi, Li Runda, Sui Yuxiu
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, China.
Brain Imaging Behav. 2025 Feb;19(1):175-188. doi: 10.1007/s11682-024-00961-z. Epub 2024 Dec 11.
Agitation is one of the core symptoms of schizophrenia. The occurrence of agitation may be related to orbitofrontal cortex dysfunction. However, due to methodological heterogeneity, the relationship between agitation and orbitofrontal cortex subregions remains unclear. Based on the multi-dimensional structure of the orbitofrontal cortex subregion, this study aims to explore the relationship between orbitofrontal cortex structure and agitation in first-episode drug-naïve patients with schizophrenia. The study subjects included 50 first-episode drug-naïve patients with schizophrenia and 29 healthy controls. All participants underwent structure magnetic resonance imaging scanning. The patients' clinical symptoms were assessed using the Positive and Negative Syndrome Scale, and the agitation were evaluated using the Brief Agitation Rating Scale. SPSS 26.0 was used to compare the differences in the orbitofrontal cortex subregion between the two groups in different structure dimensions and then conduct a Pearson's partial correlations analysis to observe the relationship between orbitofrontal cortex subregion structure and agitation. There were no significant differences in demographic factors between the two groups. Our results show the folding index of the orbitofrontal cortex subregion in patients with schizophrenia were significantly smaller compared to the healthy controls. The surface area in the orbitofrontal cortex subregion is significantly negatively correlated with agitation in first-episode drug-naïve schizophrenia patients. These results suggest that structure alterations in the orbitofrontal cortex subregion may be involved in schizophrenia agitation.
激越为精神分裂症的核心症状之一。激越的发生可能与眶额叶皮质功能障碍有关。然而，由于方法学的异质性，激越与眶额叶皮质亚区之间的关系仍不明确。基于眶额叶皮质亚区的多维结构，本研究旨在探讨首发未用药精神分裂症患者眶额叶皮质结构与激越之间的关系。研究对象包括50例首发未用药精神分裂症患者和29名健康对照者。所有参与者均接受了结构磁共振成像扫描。采用阳性和阴性症状量表评估患者的临床症状，采用简明激越评定量表评估激越情况。使用SPSS 26.0比较两组在不同结构维度上眶额叶皮质亚区的差异，然后进行Pearson偏相关分析，以观察眶额叶皮质亚区结构与激越之间的关系。两组在人口统计学因素上无显著差异。我们的结果显示，与健康对照者相比，精神分裂症患者眶额叶皮质亚区的折叠指数显著更小。在首发未用药精神分裂症患者中，眶额叶皮质亚区的表面积与激越显著负相关。这些结果表明，眶额叶皮质亚区的结构改变可能与精神分裂症激越有关。
