Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
Psychiatry Res Neuroimaging. 2016 Apr 30;250:29-32. doi: 10.1016/j.pscychresns.2016.03.005. Epub 2016 Mar 19.
An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.
已有研究报道，在精神分裂症谱系中存在眶额回沟回模式改变，但目前尚不清楚与健康受试者相比，此类患者在中间和后眶沟数量上是否也存在差异。本项磁共振成像研究调查了 102 例精神分裂症患者、47 例精神分裂样障碍患者和 84 例对照者的这些沟回数量。与对照组相比，两组患者双侧的这两条沟回数量均显著减少，且与阴性症状的严重程度呈弱相关。我们的研究结果可能反映了与精神分裂症易感性相关的神经发育病理学。
