Ford Pierce W, Narasimhan Mythreyi, Bennett Eric J
School of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA.
School of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Cell Rep. 2024 Dec 24;43(12):115050. doi: 10.1016/j.celrep.2024.115050. Epub 2024 Dec 10.
Translation control mechanisms connect the largely static genome to the highly dynamic proteome. At each step in the translation cycle, multiple layers of regulation enable efficient protein biogenesis under optimal conditions and mediate responses to acute environmental challenges. Recent research has demonstrated that individual ribosomal protein ubiquitylation events act as molecular signals to specify quality control pathway outcomes. Here, we synthesize current knowledge of ubiquitin-mediated translation control mechanisms and highlight key outstanding questions. We compare and contrast ubiquitin-dependent mechanisms that regulate ribosome-associated quality control pathways at several steps in the translation cycle. We also explore how distinct ribosome ubiquitylation events on specific ribosomal proteins impact translation activity and how defects in specific ubiquitin-mediated regulatory steps impact physiology and health.
翻译控制机制将基本静态的基因组与高度动态的蛋白质组联系起来。在翻译循环的每一步，多层调控使得在最佳条件下能高效进行蛋白质生物合成，并介导对急性环境挑战的反应。最近的研究表明，单个核糖体蛋白泛素化事件作为分子信号来确定质量控制途径的结果。在此，我们综合了关于泛素介导的翻译控制机制的现有知识，并突出了关键的悬而未决的问题。我们比较和对比了在翻译循环的几个步骤中调节核糖体相关质量控制途径的泛素依赖性机制。我们还探讨了特定核糖体蛋白上不同的核糖体泛素化事件如何影响翻译活性，以及特定泛素介导的调控步骤中的缺陷如何影响生理和健康。
