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Targeting S1PR2 in Sepsis, One Fragmented Mitochondrion at a Time.

作者信息

He Chao, Larson-Casey Jennifer L

机构信息

Department of Medicine Baylor College of Medicine Houston, Texas.

Department of Medicine University of Alabama at Birmingham Birmingham, Alabama.

出版信息

Am J Respir Cell Mol Biol. 2025 Jun;72(6):603-604. doi: 10.1165/rcmb.2024-0561ED.

DOI:10.1165/rcmb.2024-0561ED
PMID:39661949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143402/
Abstract
摘要

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本文引用的文献

1
Macrophage S1PR2 Drives Sepsis-induced Immunosuppression by Exacerbating Mitochondrial Fragmentation.巨噬细胞S1PR2通过加剧线粒体碎片化驱动脓毒症诱导的免疫抑制。
Am J Respir Cell Mol Biol. 2025 Jun;72(6):615-626. doi: 10.1165/rcmb.2024-0161OC.
2
Restoring the infected powerhouse: Mitochondrial quality control in sepsis.修复感染的动力工厂:脓毒症中的线粒体质量控制。
Redox Biol. 2023 Dec;68:102968. doi: 10.1016/j.redox.2023.102968. Epub 2023 Nov 23.
3
Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes.揭示脓毒症的异质性:亚表型的比较分析。
Intensive Care Med. 2023 Nov;49(11):1360-1369. doi: 10.1007/s00134-023-07239-w. Epub 2023 Oct 18.
4
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.鉴定脓毒症的分子表型:两项前瞻性观察队列研究的分析和两项随机对照试验的二次分析。
Lancet Respir Med. 2023 Nov;11(11):965-974. doi: 10.1016/S2213-2600(23)00237-0. Epub 2023 Aug 23.
5
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions.鞘氨醇-1-磷酸受体调节剂在多发性硬化症及其他病症中的应用
Lancet. 2021 Sep 25;398(10306):1184-1194. doi: 10.1016/S0140-6736(21)00244-0. Epub 2021 Jun 24.
6
Post-translational regulation of PGC-1α modulates fibrotic repair.PGC-1α 的翻译后调控调节纤维化修复。
FASEB J. 2021 Jun;35(6):e21675. doi: 10.1096/fj.202100339R.
7
Mitochondrial quality control in pulmonary fibrosis.肺纤维化中的线粒体质量控制。
Redox Biol. 2020 Jun;33:101426. doi: 10.1016/j.redox.2020.101426. Epub 2020 Jan 8.
8
NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.NOX4 调节石棉肺中巨噬细胞表型和线粒体生物发生。
JCI Insight. 2019 Aug 22;4(16):126551. doi: 10.1172/jci.insight.126551.
9
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.新型败血症临床表型的推导、验证及潜在治疗意义。
JAMA. 2019 May 28;321(20):2003-2017. doi: 10.1001/jama.2019.5791.
10
Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression.遗传多态性对人类免疫细胞基因表达的影响。
Cell. 2018 Nov 29;175(6):1701-1715.e16. doi: 10.1016/j.cell.2018.10.022. Epub 2018 Nov 15.