气喘吁吁：哮喘中的低氧诱导因子2α（HIF2α）
Gasping for air: HIF2α in asthma.
作者信息
Giri Shilpi, Poholek Amanda C
机构信息
Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Immunity. 2024 Dec 10;57(12):2710-2712. doi: 10.1016/j.immuni.2024.11.015.
Abstract
Despite protective roles in various type of infection and in would healing, T helper (Th)2 cells are drivers of inflammation in allergic asthma. In this issue of Immunity, Zou et al. demonstrate the crucial involvement of hypoxia inducible factor (HIF)2α in promoting the differentiation of inflammatory Th2 cells, suggesting HIF2α as a promising therapeutic target for the treatment of allergic asthma.
摘要
尽管辅助性T（Th）2细胞在各种类型的感染和伤口愈合中具有保护作用，但它们却是过敏性哮喘炎症的驱动因素。在本期《免疫》杂志中，邹等人证明了缺氧诱导因子（HIF）2α在促进炎症性Th2细胞分化中起关键作用，这表明HIF2α是治疗过敏性哮喘的一个有前景的治疗靶点。
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本文引用的文献
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Immunity. 2024 Dec 10;57(12):2808-2826.e8. doi: 10.1016/j.immuni.2024.11.001. Epub 2024 Nov 27.
2
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Immunohorizons. 2022 Aug 4;6(8):569-580. doi: 10.4049/immunohorizons.2200002.
3
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J Exp Med. 2022 Jun 6;219(6). doi: 10.1084/jem.20211985. Epub 2022 May 9.
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Fac Rev. 2021 Mar 15;10:30. doi: 10.12703/r/10-30. eCollection 2021.
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Cell. 2021 Mar 18;184(6):1469-1485. doi: 10.1016/j.cell.2021.02.016. Epub 2021 Mar 11.
6
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