Higashioka Kazuhiko, Rao Deepak A
Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Immunity. 2024 Dec 10;57(12):2715-2717. doi: 10.1016/j.immuni.2024.11.012.
Rheumatoid arthritis (RA) is driven by antigen-specific T cell responses targeting the joints. MacDonald et al. define the range of dendritic cell (DC) populations within joints of RA patients and highlight specific iDC3 and DC2 populations enriched in inflamed RA synovium that promote T cell activation as well as tolerogenic AXL DC2s in healthy synovium that are lost in RA.
类风湿性关节炎（RA）是由靶向关节的抗原特异性T细胞反应驱动的。麦克唐纳等人确定了RA患者关节内树突状细胞（DC）群体的范围，并强调了在炎症性RA滑膜中富集的特定iDC3和DC2群体，它们促进T细胞活化，以及健康滑膜中在RA中丢失的耐受性AXL DC2。
