Wang Xiao, Huo Haoling, Cao Lin, Zhong Yanming, Gong Jin, Lin Zhidan, Xie Xiaobao, Bao Zhen, Zhang Peng
Institute of Advanced Wear & Corrosion Resistant and Functional Materials, National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China.
Institute of Advanced Wear & Corrosion Resistant and Functional Materials, National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology, Jinan University, Guangzhou 510632, China.
J Control Release. 2025 Feb 10;378:153-169. doi: 10.1016/j.jconrel.2024.12.012. Epub 2024 Dec 12.
Diabetic wound healing remains a challenge due to high levels of oxidative stress, excessive inflammation, and bacterial infection. Smart dressings loaded with natural active monomers are proving to be effective strategies for enhancing diabetic wound healing. Herein, the bio-composites (PTIGA-Cur and PTIGA-Cur-Ag) with curcumin (Cur) responsive release were reported for promoting angiogenesis and diabetic wound repair, showing excellent anti-inflammatory, antioxidant, and antibacterial properties. The integration of three-dimensional networks and chemical bonds endowed the bio-composites with superior thermodynamic, mechanical, and self-healing properties. Notably, pH-responsive Schiff base as well as ester groups in the matrix enable the Cur to be released in a controlled manner. A biosensor assembled from PTIGA-Cur-Ag demonstrated electronic conductivity based on in-situ synthesis of AgNPs, which enabled sensitive monitoring of blood glucose levels. In addition, the release of AgNPs enhanced the antibacterial and anti-inflammatory properties. Expectedly, the bio-composites exhibited remarkable biocompatibility, effectively promoting the polarization of macrophages to M2 phenotype, and reducing the expression of proinflammatory cytokines. The full-thickness diabetic wound model revealed that PTIGA-Cur and PTIGA-Cur-Ag were able to effectively promote collagen deposition, neovascularization, and granulation tissue regeneration through their anti-inflammatory, antioxidant, and antibacterial properties. This study provides evidence supporting the potential utility of bio-composites with both pro-healing properties and monitoring functions in the management of diabetic wounds.
由于高水平的氧化应激、过度炎症和细菌感染，糖尿病伤口愈合仍然是一个挑战。负载天然活性单体的智能敷料被证明是增强糖尿病伤口愈合的有效策略。在此，报道了具有姜黄素（Cur）响应释放功能的生物复合材料（PTIGA-Cur和PTIGA-Cur-Ag），用于促进血管生成和糖尿病伤口修复，显示出优异的抗炎、抗氧化和抗菌性能。三维网络和化学键的整合赋予了生物复合材料卓越的热力学、机械和自愈性能。值得注意的是，基质中的pH响应席夫碱以及酯基使Cur能够以可控方式释放。由PTIGA-Cur-Ag组装的生物传感器基于AgNPs的原位合成表现出电子导电性，能够灵敏地监测血糖水平。此外，AgNPs的释放增强了抗菌和抗炎性能。预期地，生物复合材料表现出显著的生物相容性，有效地促进巨噬细胞向M2表型极化，并降低促炎细胞因子的表达。全层糖尿病伤口模型表明，PTIGA-Cur和PTIGA-Cur-Ag能够通过其抗炎、抗氧化和抗菌性能有效地促进胶原蛋白沉积、新血管形成和肉芽组织再生。本研究提供了证据，支持具有促进愈合特性和监测功能的生物复合材料在糖尿病伤口管理中的潜在效用。
