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The Challenges of Modulating Neuroinflammation in Alzheimer's Disease and Multiple Sclerosis with TREM2 Agonistic Antibodies.

作者信息

Houchois Juliette R, Attwood Jonathan E

机构信息

Oxford Medical School, University of Oxford, Oxford OX3 9DU, United Kingdom

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.

出版信息

J Neurosci. 2024 Dec 11;44(50):e1869242024. doi: 10.1523/JNEUROSCI.1869-24.2024.

DOI:10.1523/JNEUROSCI.1869-24.2024
PMID:39663111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11638803/
Abstract
摘要

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Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease.激动 TREM2 受体的激动性抗体——阿尔茨海默病治疗的新靶点。
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本文引用的文献

1
Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer's Disease and Multiple Sclerosis.TREM2 激动剂抗体在阿尔茨海默病和多发性硬化症的临床前模型中的中性或有害作用。
J Neurosci. 2024 Jul 17;44(29):e2347232024. doi: 10.1523/JNEUROSCI.2347-23.2024.
2
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain.鉴定衰老和阿尔茨海默病模型小鼠大脑中表达 TREM2 的衰老小胶质细胞。
Nat Neurosci. 2024 Jun;27(6):1116-1124. doi: 10.1038/s41593-024-01620-8. Epub 2024 Apr 18.
3
Impact of structural modifications of IgG antibodies on effector functions.IgG 抗体结构修饰对效应功能的影响。
Front Immunol. 2024 Jan 8;14:1304365. doi: 10.3389/fimmu.2023.1304365. eCollection 2023.
4
Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia.髓系细胞表达的触发受体 2 在神经炎症中的作用——被忽视的小胶质细胞的多维调控。
Neurochem Int. 2023 Dec;171:105639. doi: 10.1016/j.neuint.2023.105639. Epub 2023 Nov 3.
5
Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease.激动 TREM2 受体的激动性抗体——阿尔茨海默病治疗的新靶点。
Lancet Neurol. 2023 Nov;22(11):1048-1060. doi: 10.1016/S1474-4422(23)00247-8.
6
A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease.一种四价 TREM2 激动性抗体可减少阿尔茨海默病小鼠模型中的淀粉样蛋白病理。
Sci Transl Med. 2022 Sep 7;14(661):eabq0095. doi: 10.1126/scitranslmed.abq0095.
7
The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis.小胶质细胞和星形胶质细胞在吞噬作用和髓鞘形成中的作用：多发性硬化症的铜绿假单胞菌模型的见解。
Glia. 2022 Jul;70(7):1215-1250. doi: 10.1002/glia.24148. Epub 2022 Feb 2.
8
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.预先激活状态塑造了小胶质细胞对阿尔茨海默病小鼠模型中抗人 TREM2 的反应。
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3). doi: 10.1073/pnas.2017742118.
9
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.小胶质细胞上的 TREM2 激活促进多发性硬化模型中的髓鞘碎片清除和再髓鞘化。
Acta Neuropathol. 2020 Oct;140(4):513-534. doi: 10.1007/s00401-020-02193-z. Epub 2020 Aug 9.
10
TREM2 - a key player in microglial biology and Alzheimer disease.TREM2 - 小胶质细胞生物学和阿尔茨海默病的关键因素。
Nat Rev Neurol. 2018 Nov;14(11):667-675. doi: 10.1038/s41582-018-0072-1.