Pereira Inês Miguel, Pereira Marta, Lopes José António, Gameiro Joana
Clínica Universitária de Nefrologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Serviço de Nefrologia e Transplantação Renal, ULS Santa Maria, Lisboa, Portugal.
Nephrol Dial Transplant. 2025 Apr 1;40(4):641-650. doi: 10.1093/ndt/gfae274.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis and a leading cause of kidney failure, with limited treatment options available. The pathophysiology of IgAN remains unclear; however, recent studies suggest that genetic, epigenetic and environmental factors play significant roles. There is also strong evidence linking the gut microbiome to the development of IgAN. In this review, we will examine the relationship between the microbiome and the pathogenesis of IgAN, as well as its potential as a target for future therapeutic interventions.
免疫球蛋白A肾病（IgAN）是最常见的原发性肾小球肾炎，也是肾衰竭的主要原因，可用的治疗选择有限。IgAN的病理生理学仍不清楚；然而，最近的研究表明，遗传、表观遗传和环境因素起着重要作用。也有强有力的证据将肠道微生物群与IgAN的发展联系起来。在这篇综述中，我们将研究微生物群与IgAN发病机制之间的关系，以及其作为未来治疗干预靶点的潜力。
