Wang Xin, Zhou Xu-Jie, Qiao Xue, Falchi Mario, Liu Jing, Zhang Hong
Renal Division, Peking University First Hospital, Beijing, China.
Peking University Institute of Nephrology, Beijing, China.
Theranostics. 2025 Jan 1;15(2):656-681. doi: 10.7150/thno.104631. eCollection 2025.
The interplay between multiple organs, known as inter-organ crosstalk, represents a complex and essential research domain in understanding the mechanisms and therapies for kidney diseases. The kidneys not only interact pathologically with many other organs but also communicate with other systems through various signaling pathways. It is of paramount importance to comprehend these mechanisms for the development of more efficient therapeutic strategies. Despite extensive research in IgA nephropathy (IgAN), the most common kidney disease, the elaboration mechanism of IgAN remains challenging. Numerous studies suggest that alterations in the intestinal microbiome and its metabolites are pivotal in the progression of IgAN, opening new avenues for understanding its mechanisms. Interestingly, certain presumed probiotics, such as , have been implicated in the onset of IgAN, making the exploration of gut microbiota in the context of IgAN pathogenesis even more intriguing. In this review, we summarize the status of gut microbiology studies of IgAN and explore the possible mechanisms and intervention prospects. Future research and treatment directions may increasingly emphasize systemic, multi-organ combined interventions to decelerate the advancement of kidney disease and enhance the overall prognosis of patients.
多个器官之间的相互作用，即器官间串扰，是理解肾脏疾病机制和治疗方法的一个复杂且重要的研究领域。肾脏不仅在病理上与许多其他器官相互作用，还通过各种信号通路与其他系统进行交流。理解这些机制对于开发更有效的治疗策略至关重要。尽管对最常见的肾脏疾病——IgA肾病（IgAN）进行了广泛研究，但IgAN的发病机制仍具有挑战性。大量研究表明，肠道微生物群及其代谢产物的改变在IgAN的进展中起关键作用，为理解其机制开辟了新途径。有趣的是，某些假定的益生菌，如……，已被认为与IgAN的发病有关，这使得在IgAN发病机制背景下探索肠道微生物群变得更加引人入胜。在本综述中，我们总结了IgAN肠道微生物学研究的现状，并探讨了可能的机制和干预前景。未来的研究和治疗方向可能会越来越强调系统性、多器官联合干预，以减缓肾脏疾病的进展，提高患者的整体预后。
