Fakih-Gomez Nabil, Manay Roshini, Nazari Shahriar, Martins Lessandro, Muñoz-Gonzalez Cristina
Department of Facial Plastic & Cranio-Maxillo-Facial Surgery, Fakih Hospital, Khaizaran, Lebanon.
Department of Surgery, University of Salamanca, Salamanca, Spain.
Aesthetic Plast Surg. 2024 Dec 11. doi: 10.1007/s00266-024-04562-5.
Chronic wounds present a significant challenge in clinical practice due to complications like infections and prolonged healing times. Conventional treatments often fall short, necessitating advancements in wound healing strategies. This article introduces a novel approach using a combination of adipose-derived stem cells (ADSCs) from fat and growth factors from platelet-rich fibrin (PRF) to enhance wound healing outcomes.
The Fakih-Manay fat membrane device was utilized to prepare fat membranes. Microfat was harvested and emulsified to produce nanofat, which was then combined with PRF to create a Nanofat-PRF membrane. The resulting membrane was uniform, versatile, and suture-friendly, making it ideal for various medical and surgical applications.
Between April 2019 and April 2024, 172 patients received treatment using a nanofat membrane. The membrane showed significant improvement in wound healing in various cases including diabetic foot ulcers, cleft palate surgeries, facial dermabrasion, skin necrosis, revision rhinoplasties, and post-cosmetic surgery complications. Postoperative follow-up after healing ranged from 1 to 16 months, showing high patient satisfaction and significant improvements in wound healing and no reported complications.
The nanofat membrane presents a versatile and innovative approach to enhancing healing across a broad range of medical and surgical applications. This study provides the first evidence on the method for creating these membranes, demonstrating their clinical efficacy and safety, with no reported complications over a 5-year period.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
由于感染和愈合时间延长等并发症，慢性伤口在临床实践中带来了重大挑战。传统治疗方法往往效果不佳，因此需要改进伤口愈合策略。本文介绍了一种新颖的方法，即结合脂肪来源的干细胞（ADSCs）和富含血小板纤维蛋白（PRF）中的生长因子，以提高伤口愈合效果。
使用法基赫-马奈脂肪膜装置制备脂肪膜。采集微脂肪并乳化制成纳米脂肪，然后将其与PRF结合制成纳米脂肪-PRF膜。所得膜均匀、通用且易于缝合，非常适合各种医疗和外科应用。
在2019年4月至2024年4月期间，172例患者接受了纳米脂肪膜治疗。该膜在各种病例中均显示出伤口愈合的显著改善，包括糖尿病足溃疡、腭裂手术、面部磨皮、皮肤坏死、鼻整形修复以及美容手术后并发症。愈合后的术后随访时间为1至16个月，患者满意度高，伤口愈合有显著改善，且未报告并发症。
纳米脂肪膜为增强广泛的医疗和外科应用中的愈合提供了一种通用且创新的方法。本研究首次提供了制备这些膜的方法的证据，证明了其临床疗效和安全性，在5年期间未报告并发症。
证据水平IV：本期刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述，请参阅目录或在线作者指南www.springer.com/00266 。
