Department of Burn, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.
Int Wound J. 2023 Aug;20(6):1882-1892. doi: 10.1111/iwj.14047. Epub 2022 Dec 8.
Platelet-rich plasma (PRP) has attracted attention because of its potential to accelerate the wound healing process. However, resources for evaluating research trends in the treatment of wounds with PRP were limited. In this study, we aimed to make a bibliometric analysis of the literature related to PRP in the treatment of wounds and explore the research status, hotspots and frontiers in this field in recent 20 years. Studies about PRP treatment for wounds from 2002 to 2021 were retrieved from the Science Citation Index Expanded (SCI-E) of Web of Science (WOS) database. Visualisation softwares such as VOSviewer and SCImago Graphica, and CiteSpace were used to analyse the research trends and features. A total of 1748 studies were identified in the SCI-Expanded from 2002 to 2021. The number of publications on PRP in the treatment of wounds has shown an increasing trend, from 6 (in 2002) to 228 (in 2021). The papers published in the United States have led in times cited (14637) and H-index (63). Though Italy was slightly lower than China in the number of publications, the H-index and average cited (47, 28.45) were higher than that of China (38, 27.01). The strongest keyword was "fibrin" (strength = 13.07), and the longest burst duration keyword was "thrombin" (began in 2002 and ended in 2014). The largest 10 co-citation clusters are as follows: endothelial cell proliferation (#0), regenerative medicine-associated treatment (#1), diabetic wound healing (#2), autologous derived (#3), platelet-rich fibrin (#4), tissue engineering (#5), regenerative potential (#6), clinical randomised trial (#7), histologic observation (#8), and wound bacteria (#9). The United States has made the most outstanding contribution in this field. Chinese researchers need to enhance the quality of publications further. Wound Repair Regen. is the most noteworthy journal. The mechanism of growth factors of PRP, combination therapy, preparation of PRP, and related clinical trials may be topics that need attention.
富血小板血浆（PRP）因其加速伤口愈合过程的潜力而受到关注。然而，评估 PRP 治疗伤口的研究趋势的资源有限。在这项研究中，我们旨在对 20 年来与 PRP 治疗伤口相关的文献进行文献计量分析，并探讨该领域的研究现状、热点和前沿。从 Web of Science（WOS）数据库的科学引文索引扩展版（SCI-E）中检索了 2002 年至 2021 年有关 PRP 治疗伤口的研究。使用可视化软件（如 Vosviewer 和 Scimagographica 以及 CiteSpace）分析研究趋势和特征。在 2002 年至 2021 年期间，从 SCI-Expanded 中确定了 1748 项研究。PRP 治疗伤口的出版物数量呈上升趋势，从 2002 年的 6 篇增加到 2021 年的 228 篇。美国发表的论文在被引次数（14637）和 H 指数（63）方面处于领先地位。虽然意大利在发表论文的数量上略低于中国，但 H 指数和平均引用量（47，28.45）高于中国（38，27.01）。最强的关键词是“纤维蛋白”（强度=13.07），最长爆发持续时间的关键词是“凝血酶”（始于 2002 年，止于 2014 年）。最大的 10 个共被引聚类如下：内皮细胞增殖（#0）、再生医学相关治疗（#1）、糖尿病伤口愈合（#2）、自体来源（#3）、富血小板纤维蛋白（#4）、组织工程（#5）、再生潜能（#6）、临床随机试验（#7）、组织学观察（#8）和伤口细菌（#9）。美国在该领域做出了最杰出的贡献。中国研究人员需要进一步提高出版物的质量。Wound Repair Regen. 是最值得关注的期刊。PRP 生长因子的作用机制、联合治疗、PRP 的制备以及相关的临床试验可能是需要关注的话题。
