Yıldırım Engin, Görkem Ümit
Malatya Turgut Özal University Faculty of Medicine, Department of Obstetrics and Gynecology, Malatya, Turkey.
Hitit University Faculty of Medicine, Department of Obstetrics and Gynecology, Çorum, Turkey.
Turk J Obstet Gynecol. 2024 Dec 12;21(4):280-285. doi: 10.4274/tjod.galenos.2024.65703.
Copeptin is a glycopeptide that increases under stress and is present in polycystic ovary syndrome (PCOS) patients with metabolic system disorders. We examined the relationship between copeptin and reproductive function in patients with normoglycemic PCOS with anovulatory cycles and normal weight.
Women with unexplained infertility (n=52) and women with PCOS (n=57) were included in the study. PCOS was determined using the Rotterdam criteria. Biochemical tests including estradiol, follicle-stimulating hormone, luteinizing hormone, anti-Müllerian hormone (AMH), insulin, and copeptin were performed. Serum copeptin concentrations were measured using enzyme immunoassay.
There were no significant differences in demographic data, insulin levels, and insulin resistance between the PCOS and healthy volunteers. Copeptin levels were lower in the PCOS group (p<0.001). A significant negative correlation was observed between AMH and copeptin in the control group (r=-0.402, p= 0.013). In the PCOS group, a negative correlation was observed between antral follicle count and copeptin, as well as between AMH and copeptin (r=-0.544, p<0.01). Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive value of copeptin levels. The estimated areas under the ROC curves for serum concentration were found to be statistically significant (p<0.001) with a cut-off value of 2.78 (95% confidence interval 0.701-0.896), sensitivity of 0.87, and specificity of 0.70.
This study showed that copeptin levels are lower in patients with PCOS in the absence of insulin resistance and obesity than in healthy volunteers, and there is a negative correlation between copeptin and reproductive markers.
copeptin是一种糖肽，在应激状态下会升高，存在于患有代谢系统紊乱的多囊卵巢综合征（PCOS）患者中。我们研究了血糖正常、无排卵周期且体重正常的PCOS患者中copeptin与生殖功能之间的关系。
本研究纳入了原因不明的不孕症女性（n = 52）和PCOS女性（n = 57）。PCOS采用鹿特丹标准进行诊断。进行了包括雌二醇、促卵泡生成素、促黄体生成素、抗苗勒管激素（AMH）、胰岛素和copeptin在内的生化检测。血清copeptin浓度采用酶免疫法测定。
PCOS患者与健康志愿者在人口统计学数据、胰岛素水平和胰岛素抵抗方面无显著差异。PCOS组copeptin水平较低（p < 0.001）。对照组中观察到AMH与copeptin之间存在显著负相关（r = -0.402，p = 0.013）。在PCOS组中，观察到窦卵泡计数与copeptin之间以及AMH与copeptin之间存在负相关（r = -0.544，p < 0.01）。进行了受试者工作特征（ROC）曲线分析以确定copeptin水平的预测价值。血清浓度的ROC曲线下估计面积具有统计学意义（p < 0.001），截断值为2.78（95%置信区间0.701 - 0.896），敏感性为0.87，特异性为0.70。
本研究表明，在无胰岛素抵抗和肥胖的PCOS患者中，copeptin水平低于健康志愿者，且copeptin与生殖标志物之间存在负相关。
