Smith D, Craige E
Am J Cardiol. 1985 Jan 1;55(1):205-9. doi: 10.1016/0002-9149(85)90329-7.
Maximal negative left ventricular dP/dt is widely used as a measure of isovolumic muscular relaxation of the left ventricle. In the course of canine experiments designed to elucidate the hemodynamic events responsible for the aortic component of the second heart sound, high-fidelity left ventricular pressure and dP/dt signals were recorded and accelerations detected on the root of the aorta and epicardium at the cardiac apex. The second heart sound was coincident with maximal negative dP/dt and affected its magnitude to a variable and unpredictable extent. This may account for some of the unexpected variations in magnitude of maximal negative dP/dt that have been described in various disease states and in laboratory experiments where the effects of physiologic and pharmacologic interventions have been studied.
左心室最大负向dP/dt被广泛用作左心室等容性肌肉舒张的一项衡量指标。在旨在阐明导致第二心音主动脉成分的血流动力学事件的犬类实验过程中，记录了高保真的左心室压力和dP/dt信号，并在主动脉根部和心尖的心外膜检测到加速度。第二心音与最大负向dP/dt同时出现，并在不同程度上对其大小产生可变且不可预测的影响。这可能解释了在各种疾病状态以及研究生理和药物干预效果的实验室实验中所描述的最大负向dP/dt大小的一些意外变化。
