Chen Weijie, Zhang Yueman, Li Peiying
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China.
J Cereb Blood Flow Metab. 2025 Feb;45(2):376-378. doi: 10.1177/0271678X241273623. Epub 2024 Dec 12.
Myelin is crucial for neuron health and central nervous system (CNS) function. Recent research by McNamara highlighted microglia's essential role in compacting the myelin sheath during development and their absence leads to aberrant oligodendrocyte clusters and subsequent cognitive impairment. The study revealed that the critical involvement of the TGFβ1-TGFβR1 axis in microglia-oligodendrocyte communication could influence the oligodendrocyte lipid metabolism and thereby regulate myelin integrity. Further exploration is needed to fully elucidate the dual impact of microglia on myelination, and interactions with other glial cells, holding promise for discovering new targets in myelin-related neurodegenerative and CNS disorders.
髓鞘对神经元健康和中枢神经系统（CNS）功能至关重要。麦克纳马拉最近的研究强调了小胶质细胞在发育过程中对髓鞘形成的关键作用，缺乏小胶质细胞会导致少突胶质细胞簇异常，进而导致认知障碍。该研究表明，TGFβ1-TGFβR1轴在小胶质细胞-少突胶质细胞通讯中的关键作用可能会影响少突胶质细胞的脂质代谢，从而调节髓鞘的完整性。需要进一步探索以充分阐明小胶质细胞对髓鞘形成的双重影响，以及与其他神经胶质细胞的相互作用，有望在髓鞘相关神经退行性疾病和中枢神经系统疾病中发现新的靶点。
