Kirli Bolukbas Meltem, Ozdemir Cemile, Kocak Uzel Esengul
Department of Radiation Oncology, Health Sciences University Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Türkiye.
Department of Pathology, Bahcelievler Public Hospital, Istanbul, Türkiye.
Front Oncol. 2024 Nov 27;14:1475129. doi: 10.3389/fonc.2024.1475129. eCollection 2024.
The abscopal effect refers to an anti-tumor response that occurs in areas where radiotherapy (RT) has not been directly administered but is triggered by the immune system. We presented a case of an undifferentiated pleomorphic sarcoma with three relapses that showed a complete response after distant metastatic disease. The tumor was initially detected in the left pectoral muscle. Fifteen months after adjuvant RT and chemotherapy, a nearby recurrent lesion was surgically removed. Another 15 months later, a second recurrence appeared on the left lateral chest wall. The patient underwent a third surgery and received adjuvant radiation, but distant metastases were discovered 6 months later. Shortly after a biopsy confirmed distant metastasis, all metastatic foci went into spontaneous remission. This phenomenon is identified as the abscopal effect. The patient experienced no metastasis or local recurrences during follow-up and showed a complete response to the abscopal effect for 36 months. The abscopal effect in malignant mesenchymal tumors is extremely rare.
远隔效应是指在未直接接受放射治疗（RT）的区域发生的抗肿瘤反应，而是由免疫系统触发的。我们报告了一例未分化多形性肉瘤患者，该患者出现三次复发，在远处转移疾病后显示出完全缓解。肿瘤最初在左胸肌中被检测到。辅助放疗和化疗15个月后，手术切除了附近的复发病变。又过了15个月，左外侧胸壁出现了第二次复发。患者接受了第三次手术并接受了辅助放疗，但6个月后发现了远处转移。活检证实远处转移后不久，所有转移灶均自发缓解。这种现象被确定为远隔效应。患者在随访期间未出现转移或局部复发，对远隔效应显示出36个月的完全缓解。恶性间充质肿瘤中的远隔效应极为罕见。
