Biomimetic CuCoO nanosheets reinforced with self-assembling peptide nanofibers for tumor photothermal therapy.

The flexible design and unique physical and chemical properties of self-assembled peptides have shown great potential for applications in the fields of materials science, life science, and environmental science. Peptide nanofibers (PNFs), as a kind of bioactive nanomaterials, possess excellent biocompatibility, flexible designability, and multifaceted functionalizability. In this work, we design and describe PNFs that self-assembled by peptide molecules as carriers for bimetallic nanosheets (BMNS), leading to the development of hybrid nanomaterials, BMNS-PNFs, with unique properties. The BMNS-PNFs exhibit a photothermal conversion efficiency (PCE) of up to 31.57%, and can be used as a potential nanoplatform for photothermal therapy (PTT) of lung tumour cells. Through the results, it is shown that the PNFs can reduce the cytotoxicity of BMNS-PNFs and that BMNS-PNFs have excellent cancer cell killing effects, with photothermal killing rates of more than 95% and 90% for lung cancer cells HCC2279 and PC9, respectively. Finally, the comprehensive PTT performance of BMNS-PNFs is analysed by Ranking of Efficiency Performance (REP), and the REP value of BMNS-PNFs is calculated to be 0.741. The peptide sequences used to assemble into PNFs in this study are instructive for functional design and structural modulation of molecular self-assembly, and the constructed bimetallic-biomolecular hybrid materials provide a potential strategy for medical bioengineering.