State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Department of Periodontology, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.
Eur J Med Chem. 2024 Jun 5;272:116508. doi: 10.1016/j.ejmech.2024.116508. Epub 2024 May 15.
The traditional clinical approaches for oral cancer consist of surgery, chemotherapy, radiotherapy, immunotherapy, and so on. However, these treatments often induce side effects and exhibit limited efficacy. Photothermal therapy (PTT) emerges as a promising adjuvant treatment, utilizing photothermal agents (PTAs) to convert light energy into heat for tumor ablation. Another innovative approach, photodynamic therapy (PDT), leverages photosensitizers (PSs) and specific wavelength laser irradiation to generate reactive oxygen species (ROS), offering an effective and non-toxic alternative. The relevant combination therapies have been reported in the field of oral cancer. Simultaneously, the advancement of nanomaterials has propelled the clinical application of PTT and PDT. Therefore, a comprehensive understanding of PTT and PDT is required for better application in oral cancer treatment. Here, we review the use of PTT and PDT in oral cancer, including noble metal materials (e.g., Au nanoparticles), carbon materials (e.g., graphene oxide), organic dye molecules (e.g., indocyanine green), organic molecule-based agents (e.g., porphyrin-analog phthalocyanine) and other inorganic materials (e.g., MXenes), exemplify the advantages and disadvantages of common PTAs and PSs, and summarize the combination therapies of PTT with PDT, PTT/PDT with chemotherapy, PTT with radiotherapy, PTT/PDT with immunotherapy, and PTT/PDT with gene therapy in the treatment of oral cancer. The challenges related to the PTT/PDT combination therapy and potential solutions are also discussed.
传统的口腔癌临床治疗方法包括手术、化疗、放疗、免疫疗法等。然而，这些治疗方法常常会引起副作用，疗效有限。光热疗法（PTT）作为一种有前途的辅助治疗方法，利用光热剂（PTAs）将光能转化为热能来消融肿瘤。另一种创新的方法是光动力疗法（PDT），利用光敏剂（PSs）和特定波长的激光照射来产生活性氧（ROS），提供一种有效且无毒的替代方法。相关的联合治疗方法已在口腔癌领域得到报道。同时，纳米材料的进步推动了 PTT 和 PDT 的临床应用。因此，为了更好地应用于口腔癌治疗，需要全面了解 PTT 和 PDT。在这里，我们综述了 PTT 和 PDT 在口腔癌中的应用，包括贵金属材料（如金纳米颗粒）、碳材料（如氧化石墨烯）、有机染料分子（如吲哚菁绿）、基于有机分子的试剂（如卟啉类似酞菁）和其他无机材料（如 MXenes），举例说明了常见的 PTA 和 PS 的优缺点，并总结了 PTT 与 PDT 的联合治疗、PTT/PDT 与化疗的联合治疗、PTT 与放疗的联合治疗、PTT/PDT 与免疫疗法的联合治疗以及 PTT/PDT 与基因疗法在口腔癌治疗中的应用。还讨论了 PTT/PDT 联合治疗的挑战及潜在解决方案。
