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抗富含亮氨酸胶质瘤失活蛋白1(LGI1)边缘性脑炎患者的急性双侧声带麻痹

Acute Bilateral Vocal Cord Paralysis in a Patient With Anti-Leucine-Rich Glioma-Inactivated 1 (LGI1) Limbic Encephalitis.

作者信息

Kim Joseph L, Kim Yohan, Saenz Andres

机构信息

Neurology, UT Health San Antonio, San Antonio, USA.

出版信息

Cureus. 2024 Dec 10;16(12):e75475. doi: 10.7759/cureus.75475. eCollection 2024 Dec.

Abstract

Autoimmune encephalitis is a disorder characterized by an autoantibody-mediated process that leads to brain inflammation. It is associated with neurological symptoms including cognitive issues, psychiatric problems, seizures, and autonomic dysfunctions. Anti-leucine-rich glioma-inactivated 1 limbic encephalitis (anti-LGI1 LE) is a rare type of autoimmune LE with a unique presentation, comprising neuropsychiatric disturbances, sleep disorders, and faciobrachial dystonic seizures (FBDS). While the involvement of the larynx is seen in various other autoimmune and neurological diseases, it is not a known issue with anti-LGI1 LE. The purpose of this case report is to highlight an atypical symptom - acute bilateral vocal cord failure - that unexpectedly occurred in a patient with anti-LGI1 LE.

摘要

自身免疫性脑炎是一种以自身抗体介导的过程为特征的疾病,该过程会导致脑部炎症。它与包括认知问题、精神问题、癫痫发作和自主神经功能障碍在内的神经症状有关。抗富含亮氨酸胶质瘤失活1边缘性脑炎(抗LGI1 LE)是一种罕见的自身免疫性边缘性脑炎,具有独特的表现,包括神经精神障碍、睡眠障碍和面臂肌张力障碍性癫痫发作(FBDS)。虽然喉部受累在其他各种自身免疫性和神经系统疾病中都有发现,但在抗LGI1 LE中并不是一个已知问题。本病例报告的目的是突出一种非典型症状——急性双侧声带麻痹——该症状意外出现在一名抗LGI1 LE患者身上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c6f/11631721/3d24f191fbce/cureus-0016-00000075475-i01.jpg

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