肾病综合征的发病机制：B细胞视角
The Pathogenesis of Nephrotic Syndrome: A Perspective from B Cells.
作者信息
Zhu Shifan, Zhang Jiayu, Gao Langping, Ye Qing, Mao Jianhua
机构信息
Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.
Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.
出版信息
Kidney Dis (Basel). 2024 Aug 29;10(6):531-544. doi: 10.1159/000540511. eCollection 2024 Dec.
BACKGROUND
Nephrotic syndrome is a special type of chronic kidney disease, the specific pathogenesis of which remains unclear. An increasing number of studies have suggested that B cells play an important role in the pathogenesis of nephrotic syndrome.
SUMMARY
Idiopathic nephrotic syndrome is a common kidney disease in children. While previously believed to be primarily caused by T-cell disorders, recent research has shifted its focus to B cells. Studies have shown that B cells play a significant role in the pathogenesis of NS, potentially even more so than T cells. This article provides a comprehensive review of the involvement of B cells in the development of idiopathic nephrotic syndrome.
KEY MESSAGES
B cells are involved in the pathogenesis of nephrotic syndrome by producing autoantibodies and various cytokines.
背景
肾病综合征是一种特殊类型的慢性肾脏病，其具体发病机制尚不清楚。越来越多的研究表明，B细胞在肾病综合征的发病机制中起重要作用。
总结
特发性肾病综合征是儿童常见的肾脏疾病。虽然以前认为主要由T细胞紊乱引起，但最近的研究已将重点转移到B细胞。研究表明，B细胞在肾病综合征的发病机制中起重要作用，甚至可能比T细胞更重要。本文全面综述了B细胞在特发性肾病综合征发生发展中的作用。
关键信息
B细胞通过产生自身抗体和多种细胞因子参与肾病综合征的发病机制。
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