Yu Cuicui, Zheng Bixia, Zhang Luyan, Zhang Aihua, Jia Zhanjun, Ding Guixia
Beijing Jishuitan Hospital, Captial Medical University, Beijing, China.
Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Kidney Dis (Basel). 2024 Oct 3;10(6):588-599. doi: 10.1159/000541684. eCollection 2024 Dec.
Precise regulation of cell-cell communication is vital for cell survival and normal function during embryogenesis. The Wnt protein family, a highly conserved and extensively studied group, plays a crucial role in key cell-cell signaling events essential for development and regeneration. Congenital anomalies of the kidney and urinary tract (CAKUT) represent a leading cause of chronic kidney disease in children and young adults, and include a variety of birth abnormalities resulting from disrupted genitourinary tract development during embryonic development. The incidence and progression of CAKUT may be related to the Wnt signal transduction mechanism.
This review provides a comprehensive overview of the classical Wnt signaling pathway's role in CAKUT, explores related molecular mechanisms and provides new targets and intervention methods for the future treatment of the disease.
The Wnt signal is intricately engaged in a variety of differentiation processes throughout kidney development.
在胚胎发育过程中，精确调节细胞间通讯对于细胞存活和正常功能至关重要。Wnt蛋白家族是一个高度保守且经过广泛研究的群体，在发育和再生所必需的关键细胞间信号传导事件中发挥着至关重要的作用。先天性肾脏和尿路畸形（CAKUT）是儿童和年轻人慢性肾病的主要原因，包括胚胎发育期间泌尿生殖道发育中断导致的各种出生异常。CAKUT的发病率和进展可能与Wnt信号转导机制有关。
本综述全面概述了经典Wnt信号通路在CAKUT中的作用，探讨了相关分子机制，并为该疾病的未来治疗提供了新的靶点和干预方法。
Wnt信号在整个肾脏发育过程中复杂地参与各种分化过程。
