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采用Masquelet技术和Ilizarov环形外固定架治疗股骨远端感染性骨不连的疗效

Outcomes of Infected Non-unions of Distal Femur Managed with the Masquelet Method and Ilizarov Ring Fixator.

作者信息

Rathod Aradhana, Krishnamurthy Rameshkrishna, Shivanna Deepak, Raju Putta Kempa, Manandi Prabhu

机构信息

Orthopaedics Department, Bangalore Medical College and Research Institute, Bengaluru, India.

出版信息

Indian J Orthop. 2024 Oct 27;58(12):1815-1826. doi: 10.1007/s43465-024-01279-0. eCollection 2024 Dec.

Abstract

BACKGROUND

Distal femur infected non-union management is very challenging especially when there is late presentation and after multiple intervention. Various methods have been described and studied in the literature for infected non-union of femur which includes bone transport by fixators (ring fixators/monolateral frames) and by Masquelet method.

OBJECTIVES

To study the clinical and radiological outcomes and study the effect on quality of life by patient-reported outcomes (EQ5D5L) and VAS (Visual Analog Scale) score in patients of infected non-union of distal femur managed with combination of Masquelet method and Ilizarov ring fixator.

PATIENTS AND METHODS

Eleven patients aged between 18 and 60 years, both sexes, presenting with infected non-union of distal femur were considered for the study. Average findings were: time of presentation-56 weeks post-injury, number of previous surgeries-2.1, bone loss after debridement-8.5 cm, pre-operative VAS score-8.4, pre-operative EQ5D5L score-21.4, ISS-55.6, NUSS-56.54. Surgery was performed in two stages. Stage one involved debridement, application of a knee-spanning ring fixator, a vancomycin-loaded poly methyl methacrylate cement spacer, and closure, with corticotomy performed in some patients during this or the second stage.

RESULTS

The three patients (27.3%) had graft infection and underwent gradual docking after debridement. The results calculated for eight patients (without graft infection 72.7%) are as follows: Average ROM of knee 0 to 29.3degrees, external fixator duration was 48.1 weeks, union time was 27.5 weeks, VAS score was 1.9, immediate post-operative and 6 months frame removal EQ5D5L scores were 13.8 and 10.6, respectively. ASAMI bone score was excellent in five (62.5%), good in two (25%), and fair in one (12.5%). ASAMI functional score was excellent in one (12.5%), good in six (75%), and fair in one (12.5%).

CONCLUSION

Masquelet method with stabilization using Ilizarov ring fixator with or without lengthening can give promising results in patients with less infection severity score. Patients with high score should be managed by only fixators (ring/monolateral).

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s43465-024-01279-0.

摘要

背景

股骨远端感染性骨不连的治疗极具挑战性,尤其是在就诊较晚且经过多次干预之后。文献中已描述并研究了多种治疗股骨感染性骨不连的方法,包括使用固定架(环形固定架/单侧框架)进行骨搬运以及采用Masquelet技术。

目的

研究采用Masquelet技术联合Ilizarov环形固定架治疗股骨远端感染性骨不连患者的临床和影像学结果,并通过患者报告结局(EQ5D5L)和视觉模拟量表(VAS)评分评估对生活质量的影响。

患者与方法

本研究纳入了11例年龄在18至60岁之间、患有股骨远端感染性骨不连的患者,男女不限。平均情况如下:受伤至就诊时间为56周,既往手术次数为2.1次,清创后骨缺损8.5厘米,术前VAS评分为8.4分,术前EQ5D5L评分为21.4分,损伤严重程度评分(ISS)为55.6分,营养状况评分(NUSS)为56.54分。手术分两个阶段进行。第一阶段包括清创、应用跨膝关节环形固定架、植入含万古霉素的聚甲基丙烯酸甲酯骨水泥间隔物并缝合,部分患者在此阶段或第二阶段进行截骨术。

结果

3例患者(27.3%)出现植骨感染,清创后进行逐步对接。8例未发生植骨感染的患者(72.7%)的结果如下:膝关节平均活动范围为0至29.3度,外固定架使用时间为48.1周,骨愈合时间为27.5周,VAS评分为1.9分,术后即刻及外固定架拆除后6个月的EQ5D5L评分分别为13.8分和10.6分。根据日本骨科学会(ASAMI)骨评分标准,5例(62.5%)为优,2例(25%)为良,1例(12.5%)为可。根据ASAMI功能评分标准,1例(12.5%)为优,6例(75%)为良,1例(12.5%)为可。

结论

对于感染严重程度评分较低的患者,采用Masquelet技术联合Ilizarov环形固定架进行稳定治疗(有或无延长)可取得较好效果。对于评分较高的患者,应仅采用固定架(环形/单侧)进行治疗。

补充信息

在线版本包含可在10.1007/s43465-024-01279-0获取的补充材料。

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