Joint Reconstruction Research Center, IKHC, Tehran University of Medical Science, Tehran, Iran.
Cancer Institute, IKHC, Tehran University of Medical Science, Tehran, Iran.
BMC Musculoskelet Disord. 2024 Jan 2;25(1):26. doi: 10.1186/s12891-023-07091-5.
Large bone defects require complex treatment, multidisciplinary resources, and expert input, with surgical procedures ranging from reconstruction and salvage to amputation. The aim of this study was to provide the results of a case series of open comminuted intra-articular distal femoral fractures with significant bone loss that were managed by early fixation using anatomical plates and a modified Masquelet technique with the addition of surgical propylene mesh.
This retrospective study included all patients referred to our institution with OTA/AO C3 distal femur open fractures and meta-diaphyseal large bone loss between April 2019 and February 2021. We treated the fractures with irrigation and debridement, acute primary screw and plate fixation in the second look operation, and Masquelet method using shell-shaped antibiotic beads supplemented by propylene surgical mesh to keep the cements in place. The second step of the procedure was conducted six to eight weeks later with bone grafting and mesh augmentation to contain bone grafts. Surprisingly, hard callus formation was observed in all patients at the time of the second stage of Masquelet procedure.
All five patients' articular and meta-diaphyseal fractures with bone loss healed without major complications. The average union time was 159 days. The mean knee range of motion was 5-95 degrees. The average Lower Extremity Functional Score (LEFS) was 49 out of 80.
Combination of early plate fixation and the modified Masquelet technique with polypropylene mesh is an effective method for managing large bone defects in open intra-articular distal femoral fractures with bone loss, resulting in shorter union time possibly associated with the callus formation process. This technique may also be applicable to the management of other similar fractures specially in low-income and developing areas.
大骨缺损需要复杂的治疗、多学科资源和专家意见,手术治疗包括重建和挽救到截肢。本研究旨在提供一组开放性粉碎性关节内股骨远端骨折伴严重骨丢失的病例系列结果,这些骨折采用解剖钢板早期固定,并采用改良的 Masquelet 技术,加入外科用丙烯网片。
本回顾性研究纳入了 2019 年 4 月至 2021 年 2 月期间因 OTA/AO C3 型股骨远端开放性骨折和骨干大段骨缺损转诊至我院的所有患者。我们采用灌洗清创术,在第二次手术中进行急性初次螺钉和钢板固定,以及使用贝壳形抗生素珠的改良 Masquelet 技术,并用丙烯外科网片来保持骨水泥的位置。第二步在 6-8 周后进行,采用植骨和网片增强来固定植骨。令人惊讶的是,在 Masquelet 术的第二阶段,所有患者都观察到了坚硬的骨痂形成。
所有 5 例关节内和骨干骨缺损伴骨丢失的患者均无主要并发症愈合。平均愈合时间为 159 天。平均膝关节活动度为 5-95 度。下肢功能评分(LEFS)平均为 80 分中的 49 分。
早期钢板固定与改良的 Masquelet 技术联合使用聚丙烯网片是治疗伴有骨丢失的开放性关节内股骨远端骨折大骨缺损的有效方法,可缩短愈合时间,这可能与骨痂形成过程有关。该技术也可适用于其他类似骨折的治疗,特别是在低收入和发展中地区。