Chen Qinghua, Yu Weitong, Wang Xuyi, Zhao Chenxi, Wang Pin, Sun Lin, Xu Linlin, Xu Yingying
The Second Hospital of Shandong University, Cheeloo College of Medicine of Shandong University, Shandong University, Jinan, China.
Department of Neurology Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine of Shandong University, Shandong University, Jinan, China.
Front Immunol. 2024 Nov 27;15:1444486. doi: 10.3389/fimmu.2024.1444486. eCollection 2024.
We report on a previously non-HIV-diagnosed, 47-year-old male diagnosed with diabetes mellitus (DM) and cryptococcal meningoencephalitis, who was referred to our institution for antifungal treatment. During the course of treatment, due to the development of refractory intracranial hypertension, Ommaya reservoirs were employed for cranial pressure reduction. The patient gradually recovered during subsequent antifungal therapy; however, symptoms worsened in the third month of treatment, leading to consideration of post-infectious inflammatory response syndrome (PIIRS) on examination. Once diagnosed, the symptoms improved significantly after approximately 130 days of treatment with additional corticosteroids.
我们报告了一名此前未被诊断出感染艾滋病毒的47岁男性，他被诊断患有糖尿病（DM）和隐球菌性脑膜脑炎，被转诊至我院接受抗真菌治疗。在治疗过程中，由于出现了难治性颅内高压，因此使用了Ommaya贮器来降低颅内压。患者在随后的抗真菌治疗过程中逐渐康复；然而，在治疗的第三个月症状恶化，经检查考虑为感染后炎症反应综合征（PIIRS）。一旦确诊，在额外使用皮质类固醇治疗约130天后症状显著改善。
