Correlation of bisphenol A and bisphenol S exposure with the metabolic parameters on FDG PET/CT image.

PURPOSE

Bisphenol A (BPA) and its analogs have been proved to be harmful to human health. This study aimed to assess the correlation of BPA and its major analog, Bisphenol S (BPS), with metabolic parameters within main organs using F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging.

METHODS

A retrospective analysis was conducted on patients who had undergone FDG PET/CT imaging and were also examined for BPA and BPS levels. Urine samples were collected for detection of BPA and BPS. Standardized uptake values (SUV and SUV) of main organ tissues including liver, blood, spleen, muscle, thyroid, and cerebral cortex were quantified. Statistical analysis was performed using Spearman's rank correlation.

RESULTS

Forty patients (20 female, 20 male; mean age: 56.1 ± 15.4 years) were included. Mean urine BPA and BPS concentrations were 2.1 ± 1.2 ng/mL and 1 ± 0.6 ng/mL, respectively. Urine BPA exhibited a moderate positive correlation with liver SUV ( = 0.351,  = 0.026) and SUV ( = 0.361,  = 0.022) in male. No significant correlations were found between BPA and blood, muscle, spleen, thyroid, and cerebral cortex ( > 0.05). Conversely, urine BPS demonstrated a negative correlation with thyroid SUV in male ( = -0.43,  = 0.012) and SUV ( = -0.432,  = 0.012), while a positive correlation was observed between BPS and cerebral cortex SUV in female ( = 0.366,  = 0.033).

CONCLUSION

Urinary levels of BPA and BPS exerted distinct influences on tissue metabolic parameters observed via FDG PET/CT imaging, particularly affecting the liver, thyroid, and cerebral cortex.