Xiao Liu, Wen Xue, Li Lin, Li Yuhao
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Department of Plastic and Burn Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Front Public Health. 2024 Nov 27;12:1433122. doi: 10.3389/fpubh.2024.1433122. eCollection 2024.
Bisphenol A (BPA) and its analogs have been proved to be harmful to human health. This study aimed to assess the correlation of BPA and its major analog, Bisphenol S (BPS), with metabolic parameters within main organs using F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging.
A retrospective analysis was conducted on patients who had undergone FDG PET/CT imaging and were also examined for BPA and BPS levels. Urine samples were collected for detection of BPA and BPS. Standardized uptake values (SUV and SUV) of main organ tissues including liver, blood, spleen, muscle, thyroid, and cerebral cortex were quantified. Statistical analysis was performed using Spearman's rank correlation.
Forty patients (20 female, 20 male; mean age: 56.1 ± 15.4 years) were included. Mean urine BPA and BPS concentrations were 2.1 ± 1.2 ng/mL and 1 ± 0.6 ng/mL, respectively. Urine BPA exhibited a moderate positive correlation with liver SUV ( = 0.351, = 0.026) and SUV ( = 0.361, = 0.022) in male. No significant correlations were found between BPA and blood, muscle, spleen, thyroid, and cerebral cortex ( > 0.05). Conversely, urine BPS demonstrated a negative correlation with thyroid SUV in male ( = -0.43, = 0.012) and SUV ( = -0.432, = 0.012), while a positive correlation was observed between BPS and cerebral cortex SUV in female ( = 0.366, = 0.033).
Urinary levels of BPA and BPS exerted distinct influences on tissue metabolic parameters observed via FDG PET/CT imaging, particularly affecting the liver, thyroid, and cerebral cortex.
双酚A（BPA）及其类似物已被证明对人体健康有害。本研究旨在使用氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）成像评估BPA及其主要类似物双酚S（BPS）与主要器官内代谢参数的相关性。
对接受FDG PET/CT成像并检测了BPA和BPS水平的患者进行回顾性分析。收集尿液样本检测BPA和BPS。对包括肝脏、血液、脾脏、肌肉、甲状腺和大脑皮层在内的主要器官组织的标准化摄取值（SUV和SUV）进行量化。使用Spearman等级相关性进行统计分析。
纳入40例患者（20例女性，20例男性；平均年龄：56.1±15.4岁）。尿液中BPA和BPS的平均浓度分别为2.1±1.2 ng/mL和1±0.6 ng/mL。男性尿液BPA与肝脏SUV（=0.351，=0.026）和SUV（=0.361，=0.022）呈中度正相关。未发现BPA与血液、肌肉、脾脏、甲状腺和大脑皮层之间存在显著相关性（>0.05）。相反，男性尿液BPS与甲状腺SUV（=-0.43，=0.012）和SUV（=-0.432，=0.012）呈负相关，而女性BPS与大脑皮层SUV呈正相关（=0.366，=0.033）。
尿液中BPA和BPS水平对通过FDG PET/CT成像观察到的组织代谢参数有不同影响，尤其影响肝脏、甲状腺和大脑皮层。
