Lökken P, Birkeland J M
Scand J Dent Res. 1979 Aug;87(4):275-8. doi: 10.1111/j.1600-0722.1979.tb00682.x.
In a randomized double-blind cross-over study, 19 young women received iron tablets (Neo-Fer) containing 0.20 g ferrous fumarate (60 mg Fe++), and placebo tablets, twice daily during two periods of 8 weeks each. Development of discolorations on fillings and tooth surfaces was studied by careful clinical examination, and by paired comparison of color transparencies taken before and after each period of treatment. Any tendency of this oral iron preparation to cause dental discolorations could not be detected in the present group of women with good oral hygiene. Seven participants reported gastrointestinal discomfort, two of them only when receiving placebo tablets.
在一项随机双盲交叉研究中，19名年轻女性在两个为期8周的阶段中，每天两次服用含0.20克富马酸亚铁（60毫克二价铁）的铁片（新铁）和安慰剂片。通过仔细的临床检查以及对每个治疗阶段前后拍摄的颜色透明度进行配对比较，研究补牙材料和牙齿表面变色情况。在这群口腔卫生良好的女性中，未发现这种口服铁制剂有导致牙齿变色的任何倾向。7名参与者报告有胃肠道不适，其中2人仅在服用安慰剂片时出现不适。
