Brock C, Curry H, Hanna C, Knipfer M, Taylor L
Clin Ther. 1985;7(5):568-73.
The acceptability of supplemental iron delivered from a wax-matrix tablet of ferrous sulfate was compared with that of a conventional ferrous sulfate tablet in a single-blind, parallel-group study. Both tablets were formulated to deliver 50 mg of elemental iron. The incidence of adverse effects was found to be significantly greater among 272 subjects taking the conventional tablets than among 271 subjects taking the wax-matrix preparation. Eighty-one percent of the subjects taking the wax-matrix preparation experienced no severe or moderate side effects as compared with only 50% of those taking the conventional tablets.
在一项单盲平行组研究中，比较了硫酸亚铁蜡基质片剂与传统硫酸亚铁片剂补充铁的可接受性。两种片剂均设计为提供50毫克元素铁。结果发现，272名服用传统片剂的受试者中不良反应的发生率明显高于271名服用蜡基质制剂的受试者。服用蜡基质制剂的受试者中有81%未出现严重或中度副作用，而服用传统片剂的受试者中这一比例仅为50%。
