Lee Changhee, Jung Yong Gi, Kim Hyo-Yeol, Hong Sang Duk
Departments of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
J Rhinol. 2022 Jul;29(2):106-111. doi: 10.18787/jr.2021.00387. Epub 2022 Jul 27.
Various invasive fungal infections can occur in immunocompromised hosts, and an acute invasive fungal infection (AIFI) can be fatal. Because of its high mortality rate, AIFI must be quickly diagnosed and treated, such as anti-fungal agents or surgical debridement. In an immunocompromised host, nasal herpes simplex infection, usually caused by herpes simplex virus (HSV) type-1, can have various clinical manifestations, some of which can mimic AIFI. However, the management of acute viral infection differs significantly from invasive fungal infections of the nose. A fast and accurate differential diagnosis is mandatory because a delay in the disease-specific treatment of acute invasive infections can lead to mortality. This report describes two immunocompromised patients with mucosal and skin lesions around the nose. We provide clinical clues when mucosal lesions of the nasal cavity and skin lesions around the nose develop in immunocompromised hosts.
各种侵袭性真菌感染可发生于免疫功能低下的宿主，急性侵袭性真菌感染（AIFI）可能是致命的。由于其高死亡率，必须迅速诊断和治疗AIFI，如使用抗真菌药物或手术清创。在免疫功能低下的宿主中，通常由1型单纯疱疹病毒（HSV）引起的鼻单纯疱疹感染可表现出多种临床表现，其中一些可能类似AIFI。然而，急性病毒感染的治疗与鼻部侵袭性真菌感染有显著差异。快速准确的鉴别诊断至关重要，因为急性侵袭性感染的疾病特异性治疗延迟可能导致死亡。本报告描述了两名鼻周有黏膜和皮肤病变的免疫功能低下患者。我们提供了免疫功能低下宿主鼻腔黏膜病变和鼻周皮肤病变出现时的临床线索。
