Fedeli Valeria, Wang Jingyi, Cantagrel Vincent, Saiardi Adolfo
Laboratory for Molecular Cell Biology, London WC1E 6BT, UK, University College London, London, England, United Kingdom.
Developmental Brain Disorders Laboratory, Université Paris Cité, INSERM UMR1163, Imagine Institute, 75015, Paris, France, Université Paris Cité, Paris, Île-de-France, France.
MicroPubl Biol. 2024 Nov 1;2024. doi: 10.17912/micropub.biology.001390. eCollection 2024.
Inositol hexakisphosphate (InsP ), also known as phytic acid, is a potent chelator of bivalent cations. Intracellular InsP molecules are associated with magnesium. Calcium is the prevalent bivalent cation outside the cell and its association with InsP could lead to the formation of insoluble complexes. To avoid the formation of dangerous InsP /Calcium precipitates in the bloodstream, mammals must possess a robust InsP phosphatase in their plasma. Here we identify the Multiple Inositol Polyphosphate Phosphatase 1 ( MINPP1 ) as the InsP phosphatase present in human plasma.
肌醇六磷酸（InsP₆），也被称为植酸，是一种强效的二价阳离子螯合剂。细胞内的InsP₆分子与镁相关联。钙是细胞外普遍存在的二价阳离子，它与InsP₆结合可能会导致形成不溶性复合物。为避免在血液中形成危险的InsP₆/钙沉淀物，哺乳动物血浆中必须拥有一种强大的InsP₆磷酸酶。在此，我们确定多肌醇多磷酸磷酸酶1（MINPP1）为人类血浆中存在的InsP₆磷酸酶。
