Nguyen Trung Minh, Furkert David, Fiedler Dorothea
Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Straße 10, 13125 Berlin, Germany; Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Straße 10, 13125 Berlin, Germany; Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany.
Curr Opin Chem Biol. 2022 Oct;70:102177. doi: 10.1016/j.cbpa.2022.102177. Epub 2022 Jun 30.
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules, the different modes of action they can access, and a somewhat limited chemical and analytical toolset. Herein, we summarize the most recent mechanistic insights into PP-InsP signaling, which illustrate our progress in connecting mechanism and function of PP-InsPs.
肌醇焦磷酸（PP-InsPs）是一类高电荷信使分子，在健康和疾病状态下调节核心生物学过程，如细胞内磷酸盐和整体能量稳态。由于这些分子的独特性质、它们可采用的不同作用模式以及化学和分析工具集相对有限，解读PP-InsP介导信号传导的分子机制仍然是一项挑战。在此，我们总结了关于PP-InsP信号传导的最新机制见解，这些见解阐述了我们在连接PP-InsP的机制与功能方面取得的进展。
