Freeman R K, Dorchester W, Anderson G, Garite T J
Am J Obstet Gynecol. 1985 Jan 1;151(1):7-13. doi: 10.1016/0002-9378(85)90414-4.
Among 7052 patients studied between 1976 and 1982 in a collaborative project on antepartum fetal heart rate monitoring, 337 patients had a previous stillbirth as a reason for testing. Overall a previous stillbirth history significantly increased the risk of having a positive result on a contraction stress test, primarily among hypertensive patients. Patients with a previous stillbirth also had a significantly higher incidence of respiratory distress syndrome in their neonates attributable to premature intervention for maternal indications (primarily among hypertensive women and patients with clinical intrauterine growth retardation). Low Apgar scores were found to be significantly increased in diabetics with previous stillbirths primarily due to neonates with congenital malformations. Premature intervention by labor induction or cesarean section was more common among patients with a previous stillbirth for both maternal indications and abnormal antepartum fetal heart rate studies. Previous stillbirth would appear therefore to be a significant risk factor primarily when associated with a diagnosis of hypertension or clinical intrauterine growth retardation.
在1976年至1982年期间一项关于产前胎儿心率监测的合作项目中研究的7052名患者中,有337名患者因之前有死产史而接受检查。总体而言,之前有死产史显著增加了宫缩应激试验结果为阳性的风险,主要是在高血压患者中。之前有死产史的患者,其新生儿因针对母体指征进行过早干预(主要是在高血压女性和临床宫内生长受限患者中)而发生呼吸窘迫综合征的发生率也显著更高。发现之前有死产史的糖尿病患者中,低阿氏评分显著增加,主要是由于患有先天性畸形的新生儿。对于因母体指征和产前胎儿心率研究异常而之前有死产史的患者,引产或剖宫产的过早干预更为常见。因此,之前有死产史似乎主要在与高血压诊断或临床宫内生长受限相关时才是一个重要的风险因素。