O'Keefe M, Morley K D, Haining W M, Smith A
Am J Ophthalmol. 1985 Jan 15;99(1):66-7. doi: 10.1016/s0002-9394(14)75869-6.
Two patients with rheumatoid arthritis (two women, 58 and 62 years old) developed reversible penicillamine-induced ocular myasthenia gravis. Both had the HLA-DR1 antigen, unlike most patients with idiopathic myasthenia gravis who show HLA-DR3, suggesting that penicillamine-induced myasthenia gravis and its idiopathic counterpart occur in patients with different genetic backgrounds. In both cases, cessation of drug treatment led to resolution of the symptoms.