青霉胺诱发的重症肌无力中的人类白细胞抗原和乙酰胆碱受体抗体
HLA antigens and acetylcholine receptor antibodies in penicillamine induced myasthenia gravis.
作者信息
Garlepp M J, Dawkins R L, Christiansen F T
出版信息
Br Med J (Clin Res Ed). 1983 Jan 29;286(6362):338-40. doi: 10.1136/bmj.286.6362.338.
Abstract
Antibodies to the acetylcholine receptor and HLA antigens have been studied in patients with myasthenia gravis occurring in association with penicillamine treatment. The properties of the antiacetylcholine receptor in these patients differed from those in patients with idiopathic myasthenia gravis in terms of specificity and affinity. These patients had an increased prevalence of HLA Bw35 and DR1 compared to controls and a decreased frequency of B8 and DR3 compared to patients with idiopathic myasthenia gravis. Likewise, they had a decreased frequency of DR4 compared to patients with rheumatoid arthritis. These data provide supportive evidence for a role for penicillamine in the induction of myasthenia gravis in genetically predisposed individuals.
摘要
对与青霉胺治疗相关的重症肌无力患者，已开展了针对乙酰胆碱受体和HLA抗原的抗体研究。这些患者体内抗乙酰胆碱受体的特性在特异性和亲和力方面与特发性重症肌无力患者不同。与对照组相比，这些患者中HLA Bw35和DR1的患病率增加；与特发性重症肌无力患者相比，B8和DR3的频率降低。同样，与类风湿关节炎患者相比，他们DR4的频率降低。这些数据为青霉胺在遗传易感性个体中诱发重症肌无力所起的作用提供了支持性证据。
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本文引用的文献
1
Penicillamine-induced myasthenia gravis in progressive systemic sclerosis.
Arthritis Rheum. 1980 Apr;23(4):505-8. doi: 10.1002/art.1780230414.
2
Cross-reactivity of anti-acetylcholine receptor autoantibodies.抗乙酰胆碱受体自身抗体的交叉反应性。
Muscle Nerve. 1981 Jul-Aug;4(4):282-8. doi: 10.1002/mus.880040404.
3
4
Binding affinities of anti-acetylcholine receptor autoantibodies in myasthenia gravis.重症肌无力中抗乙酰胆碱受体自身抗体的结合亲和力。
J Immunol. 1982 Jan;128(1):105-10.
5
Myasthenia gravis and D-penicillamine.
J Rheumatol Suppl. 1981 Jan-Feb;7:169-74.
6
Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.HLA-Aw31和HLA-DR1与成人类风湿性关节炎的关联。
Ann Rheum Dis. 1982 Aug;41(4):403-4. doi: 10.1136/ard.41.4.403.
7
Disease associations with complotypes, supratypes and haplotypes.疾病与补体复合体型、超型和单倍型的关联。
Immunol Rev. 1983;70:5-22. doi: 10.1111/j.1600-065x.1983.tb00707.x.
8
DR antigens and rheumatoid arthritis: a study of two populations.DR 抗原与类风湿性关节炎：对两个群体的研究。
Br Med J (Clin Res Ed). 1981 Nov 14;283(6302):1287-8. doi: 10.1136/bmj.283.6302.1287.
9
Penicillamine-associated myasthenia gravis.
Neurology. 1980 Nov;30(11):1246-9. doi: 10.1212/wnl.30.11.1246.
10
Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility.肼屈嗪诱发的系统性红斑狼疮：HLA - DR及性别对易感性的影响。
Lancet. 1980 May 24;1(8178):1107-9. doi: 10.1016/s0140-6736(80)91554-8.
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