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Five-year outcome of CD19 followed by CD22 chimeric antigen receptor T-cell therapy in B-cell acute lymphoblastic leukemia patients who relapsed after allo-transplantation.

作者信息

Liu Shuangyou, An Lihong, Yin Zhichao, Lin Yuehui, Ling Zhuojun, Deng Biping, Yu Xinjian, Zheng Qinlong, Zhao Defeng, Wu Tong, Chang Alex H, Tong Chunrong

机构信息

Department of Hematology, Beijing Gobroad Boren Hospital, Beijing.

Cytology Laboratory, Beijing Gobroad Boren Hospital, Beijing.

出版信息

Haematologica. 2025 May 1;110(5):1192-1196. doi: 10.3324/haematol.2024.286534. Epub 2024 Dec 12.

DOI:10.3324/haematol.2024.286534
PMID:39665213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12050930/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ce/12050930/4e03f6b99ad7/1101192.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ce/12050930/29a43a0c42e9/1101192.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ce/12050930/4e03f6b99ad7/1101192.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ce/12050930/29a43a0c42e9/1101192.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ce/12050930/4e03f6b99ad7/1101192.fig2.jpg

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本文引用的文献

1
Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study.ZUMA-3 研究中复发/难治性成人 B 细胞急性淋巴细胞白血病患者接受 KTE-X19 的 2 年随访及其与 SCHOLAR-3 的对比，后者为一项外部历史对照研究。
J Hematol Oncol. 2022 Dec 10;15(1):170. doi: 10.1186/s13045-022-01379-0.
2
Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial.ELIANA 试验中复发/难治性急性淋巴细胞白血病的儿科和年轻成年患者接受 tisagenlecleucel 治疗的 3 年更新结果。
J Clin Oncol. 2023 Mar 20;41(9):1664-1669. doi: 10.1200/JCO.22.00642. Epub 2022 Nov 18.
3
Blinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis.Blinatumomab 治疗儿童复发/难治性 B 细胞急性淋巴细胞白血病：RIALTO 扩展使用研究最终分析。
Blood Adv. 2022 Feb 8;6(3):1004-1014. doi: 10.1182/bloodadvances.2021005579.
4
Combination of CD19 and CD22 CAR-T cell therapy in relapsed B-cell acute lymphoblastic leukemia after allogeneic transplantation.异基因移植后复发的 B 细胞急性淋巴细胞白血病的 CD19 和 CD22 CAR-T 细胞治疗的联合应用。
Am J Hematol. 2021 Jun 1;96(6):671-679. doi: 10.1002/ajh.26160. Epub 2021 Mar 29.
5
Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children.儿童白血病或骨髓增生异常综合征（MDS）经造血细胞移植（HCT）治疗后复发的预后。
Bone Marrow Transplant. 2019 Aug;54(8):1337-1345. doi: 10.1038/s41409-019-0438-z. Epub 2019 Jan 22.
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Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.急性淋巴细胞白血病中CD19嵌合抗原受体疗法的长期随访
N Engl J Med. 2018 Feb 1;378(5):449-459. doi: 10.1056/NEJMoa1709919.
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N Engl J Med. 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866.
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Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia.博纳吐单抗对比化疗治疗晚期急性淋巴细胞白血病
N Engl J Med. 2017 Mar 2;376(9):836-847. doi: 10.1056/NEJMoa1609783.
9
Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.使用睡美人转座子系统生成CD19特异性嵌合抗原受体T细胞的I期试验。
J Clin Invest. 2016 Sep 1;126(9):3363-76. doi: 10.1172/JCI86721. Epub 2016 Aug 2.
10
Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia.表达CD19嵌合抗原受体的自体或供体来源T细胞在伴有髓外白血病的成人B淋巴细胞白血病中的耐受性和疗效
Oncoimmunology. 2015 May 26;4(11):e1027469. doi: 10.1080/2162402X.2015.1027469. eCollection 2015 Nov.