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暴发性痤疮的有效管理:两例突出荧光光能疗法的病例报告

Effective management of acne fulminans: Two case reports highlighting fluorescent light energy therapy.

作者信息

Estebaranz Jose Luis López, Bordignon Matteo, Tardugno Roberta, Nielsen Michael Canova Engelbrecht

机构信息

Dermomedic Clinic, University Hospital Fundación Alcorcón, Madrid, Spain.

Poliambulatorio San Gaetano, Research Unit, Skin Team, Thiene, Italy.

出版信息

J Cosmet Dermatol. 2025 Jan;24(1):e16478. doi: 10.1111/jocd.16478. Epub 2024 Dec 12.

DOI:10.1111/jocd.16478
PMID:39665249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11699507/
Abstract

BACKGROUND

Acne vulgaris stands as a prevailing skin condition among adolescents worldwide.

OBJECTIVES

The primary aim in addressing acne is to manage it effectively, preventing the occurrence of permanent scarring.

MATERIALS AND METHODS

This case report outlines the experiences of two adolescent boys grappling with acne fulminans. Initial treatments encompassed isotretinoin, corticosteroids, and doxycycline, until they were discontinued due to their ineffectiveness and the emergence of adverse side effects such as headaches, nausea, and vomiting. Subsequently, fluorescent light energy (FLE) therapy was introduced to tackle these severe cases.

RESULTS

After 4 months of FLE therapy, the patients exhibited significant improvements in their condition. Six months post treatment initiation, both patients have sustained a symptom free state, marked by the absence of active lesions.

CONCLUSION

FLE therapy effectively treated the acne fulminans cases reported and could be considered as a valid treatment option.

摘要

背景

寻常痤疮是全球青少年中普遍存在的皮肤疾病。

目的

治疗痤疮的主要目标是有效控制病情,防止永久性瘢痕形成。

材料与方法

本病例报告概述了两名患有暴发性痤疮的青少年男性的经历。初始治疗包括异维A酸、皮质类固醇和多西环素,直至因无效及出现头痛、恶心和呕吐等不良反应而停药。随后引入荧光光能(FLE)疗法来治疗这些严重病例。

结果

经过4个月的FLE治疗,患者病情有显著改善。治疗开始6个月后,两名患者均保持无症状状态,无活动性皮损。

结论

FLE疗法有效治疗了所报告的暴发性痤疮病例,可被视为一种有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/7234b33472f0/JOCD-24-e16478-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/9e87e00ed3e5/JOCD-24-e16478-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/a0cfce207dbc/JOCD-24-e16478-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/20b7b3f18130/JOCD-24-e16478-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/7234b33472f0/JOCD-24-e16478-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/9e87e00ed3e5/JOCD-24-e16478-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/a0cfce207dbc/JOCD-24-e16478-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/20b7b3f18130/JOCD-24-e16478-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc58/11699507/7234b33472f0/JOCD-24-e16478-g002.jpg

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Biophotonic Therapy with Fluorescent Light Energy Decreases Facial Erythema, Improves Signs and Symptoms of Rosacea, and Increases Patient Satisfaction: A Postmarket Study.荧光光能生物光子疗法可减轻面部红斑,改善酒渣鼻的体征和症状,并提高患者满意度:一项上市后研究。
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Fluorescent light energy combined with systemic isotretinoin: A 52-week follow-up evaluating efficacy and safety in treatment of moderate-severe acne.
荧光光能联合系统性异维A酸:一项评估中度至重度痤疮治疗疗效和安全性的52周随访研究
Clin Case Rep. 2021 Feb 20;9(4):2057-2068. doi: 10.1002/ccr3.3944. eCollection 2021 Apr.
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Acne fulminans induced by a low dose isotretinoin: case report and review of the literature.异维 A 酸低剂量诱导的暴发性痤疮:病例报告及文献复习。
Dermatol Online J. 2020 Dec 15;26(12):13030/qt14h2419w.
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Pediatrics. 2020 May;145(Suppl 2):S225-S230. doi: 10.1542/peds.2019-2056L.
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